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    PSEUDO-ELECTROPHEROGRAM CONSTRUCTION FROM PEPTIDE LEVEL MASS SPECTROMETRY DATA
    1.
    发明公开
    PSEUDO-ELECTROPHEROGRAM CONSTRUCTION FROM PEPTIDE LEVEL MASS SPECTROMETRY DATA 审中-公开

    公开(公告)号：US20240329052A1

    公开(公告)日：2024-10-03

    申请号：US18737836

    申请日：2024-06-07

    申请人： Protein Metrics, LLC

    发明人： Andrew NICHOLS ,  Marshall BERN ,  Yong Joo KIL ,  Eric Carlson

    IPC分类号： G01N33/68 ,  H01J49/00

    CPC分类号： G01N33/6848 ,  H01J49/0036 ,  H01J49/004

    摘要： Methods and apparatuses for the identification and/or characterization of properties of a macromolecule based on mass spectrometry data. Specifically, described herein are methods and apparatuses for converting peptide-level data into a pseudo-intact mass spectra. Also described herein are methods and apparatuses for converting peptide-level data into a pseudo-electropherogram. The methods may be well suited for analyzing proteins and protein complexes, including estimating properties of post-translational modifications of the proteins and protein complexes. Methods may include generating a theoretical graph or spectrum based on peptide-level mass spectrometry data. In some embodiments, the theoretical graph may be a theoretical intact mass spectrum or a theoretical charge distribution spectrum.

    Methods and apparatuses for determining the intact mass of large molecules from mass spectrographic data
    2.
    发明授权
    Methods and apparatuses for determining the intact mass of large molecules from mass spectrographic data 有权

    公开(公告)号：US11728150B2

    公开(公告)日：2023-08-15

    申请号：US17480037

    申请日：2021-09-20

    申请人： Protein Metrics, LLC

    发明人： Marshall Bern

    IPC分类号： H01J49/00 ,  G06N3/12 ,  H01J49/16 ,  G06N3/126

    CPC分类号： H01J49/0036 ,  G06N3/126 ,  H01J49/165

    摘要： Methods and apparatuses for the identification and/or characterization of properties of a sample using mass spectrometry. The method involves using a measured spectrum of data from a sample taken with a mass spectrometer, deconvoluting the measured spectrum of data by applying parsimony weighting to minimize the number of charge states based on one or more of: the number of intense peaks in the mass spectrum; the number of harmonic relationships (e.g., masses in small integer ratios); and the number of off-by-one relationships (e.g., m/z bins with high probability for two adjacent charges). Thus, the underlying m/z spectrum may be inferred from the family of plausible deconvoluted spectra determined by applying parsimony and the inferred m/z spectrum may be used to identify and/or characterize the sample.

    METHODS AND APPARATUSES FOR DECONVOLUTION OF MASS SPECTROMETRY DATA
    7.
    发明公开
    METHODS AND APPARATUSES FOR DECONVOLUTION OF MASS SPECTROMETRY DATA 审中-公开

    公开(公告)号：US20230268168A1

    公开(公告)日：2023-08-24

    申请号：US18309727

    申请日：2023-04-28

    申请人： Protein Metrics, LLC

    发明人： Marshall BERN

    IPC分类号： H01J49/00

    CPC分类号： H01J49/0036

    摘要： Methods and apparatuses for the identification and/or characterization of properties of a sample using mass spectrometry. Methods may include analyzing spacings between mass-to-charge ratio peaks from measured mass spectrum data, identifying and associating the spacings with mass delta values corresponding to masses of possible constituents of a molecule within the sample, calculating estimated charges of molecular species within the sample based on the spacings and mass delta values, and deconvoluting the measured mass spectrum data based on the estimated charges to provide a neutral mass spectrum. The methods and apparatuses (including software) described herein may result in more accurate characterization of peaks within the neutral mass spectrum, less false peaks within the neutral mass spectrum, and less noise in the neutral mass spectrum.

    Methods and apparatuses for deconvolution of mass spectrometry data
    8.
    发明授权
    Methods and apparatuses for deconvolution of mass spectrometry data 有权

    公开(公告)号：US12040170B2

    公开(公告)日：2024-07-16

    申请号：US18309727

    申请日：2023-04-28

    申请人： Protein Metrics, LLC

    发明人： Marshall Bern

    IPC分类号： H01J49/00

    CPC分类号： H01J49/0036

    摘要： Methods and apparatuses for the identification and/or characterization of properties of a sample using mass spectrometry. Methods may include analyzing spacings between mass-to-charge ratio peaks from measured mass spectrum data, identifying and associating the spacings with mass delta values corresponding to masses of possible constituents of a molecule within the sample, calculating estimated charges of molecular species within the sample based on the spacings and mass delta values, and deconvoluting the measured mass spectrum data based on the estimated charges to provide a neutral mass spectrum. The methods and apparatuses (including software) described herein may result in more accurate characterization of peaks within the neutral mass spectrum, less false peaks within the neutral mass spectrum, and less noise in the neutral mass spectrum.

    Pseudo-electropherogram construction from peptide level mass spectrometry data
    9.
    发明授权
    Pseudo-electropherogram construction from peptide level mass spectrometry data 有权

    公开(公告)号：US12038444B2

    公开(公告)日：2024-07-16

    申请号：US17828465

    申请日：2022-05-31

    申请人： Protein Metrics, LLC

    发明人： Andrew Nichols ,  Marshall Bern ,  Yong Joo Kil ,  Eric Carlson

    IPC分类号： G01N33/68 ,  H01J49/00

    CPC分类号： G01N33/6848 ,  H01J49/0036 ,  H01J49/004

    摘要： Methods and apparatuses for the identification and/or characterization of properties of a macromolecule based on mass spectrometry data. Specifically, described herein are methods and apparatuses for converting peptide-level data into a pseudo-intact mass spectra. Also described herein are methods and apparatuses for converting peptide-level data into a pseudo-electropherogram. The methods may be well suited for analyzing proteins and protein complexes, including estimating properties of post-translational modifications of the proteins and protein complexes. Methods may include generating a theoretical graph or spectrum based on peptide-level mass spectrometry data. In some embodiments, the theoretical graph may be a theoretical intact mass spectrum or a theoretical charge distribution spectrum.