- 专利标题: Hepatitis C virus immunogenic compositions and methods of use thereof
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申请号: US18099035申请日: 2023-01-19
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公开(公告)号: US12042536B2公开(公告)日: 2024-07-23
- 发明人: Michael Houghton , Abdolamir Landi , Carlos A. Guzman , Thomas Ebensen , Darren Hockman , John L. Law , Michael Logan
- 申请人: The Governors of the University of Alberta , Helmholtz Center for Infection Research
- 申请人地址: CA Edmonton
- 专利权人: The Governors of the University of Alberta,Helmholtz Center for Infection Research
- 当前专利权人: The Governors of the University of Alberta,Helmholtz Center for Infection Research
- 当前专利权人地址: CA Edmonton; DE Braunschweig
- 代理机构: Bozicevic, Field & Francis LLP
- 代理商 Shweta Chandra
- 主分类号: A61K39/29
- IPC分类号: A61K39/29 ; A61K39/00 ; A61K39/12 ; A61K39/39 ; A61P31/14 ; A61P37/04 ; C01F11/02 ; C07D323/00 ; C07K14/005 ; C07K14/18 ; C07K14/28 ; C07K14/33 ; C07K14/34 ; C12N15/86
摘要:
The present disclosure provides immunogenic compositions comprising: a) hepatitis C virus (HCV) E1E2 heterodimers, HCV E2, or HCV E1; and b) an adjuvant, where the adjuvant is a cyclic dinucleotide or an archaeosome. The present disclosure provides methods of inducing an immune response in an individual to HCV, the methods comprising administering to an individual an effective amount of an immunogenic composition of the present disclosure.
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