An information handling system includes a hardware processor, a memory device, and a PMU to provide power to the processor and memory device. The information handling system includes an ion emitter/collector cooling system including an ion emitter and an ion collector, the ion emitter to generate ions from the atmosphere and the ion collector to collect and deionize those ions, the creation of ions by the ion emitter creating an airflow through and out of the ion collector and at least one sensor to detect and measure at least one non-static ozone predictor measurement describing ozone production at the ion emitter/collector cooling system. Further, the processor executing code instructions of an intelligent ozone estimation and mitigation system including a trained ozone estimation machine learning model to use, as input, the non-static ozone predictor measurement and provide, as output, an ozone estimation value estimating the amount of ozone produced at the ion emitter.