Invention Grant
- Patent Title: Antibody library and antibody screening method using same
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Application No.: US17058124Application Date: 2019-05-31
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Publication No.: US12071710B2Publication Date: 2024-08-27
- Inventor: Dong-Sik Kim , Mi Jung Lee , Mi Young Oh , Hye-Ji Choi , Gil-Jung Kim , Shin A Jang , Ae Rin Yoon
- Applicant: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
- Applicant Address: KR Gyeonggi-do
- Assignee: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
- Current Assignee: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
- Current Assignee Address: KR Gyeonggi-Do
- Agency: HULTQUIST, PLLC
- Agent Steven J. Hultquist
- Priority: KR 20180063306 2018.06.01
- International Application: PCT/KR2019/006565 2019.05.31
- International Announcement: WO2019/231276A 2019.12.05
- Date entered country: 2021-05-23
- Main IPC: C40B40/10
- IPC: C40B40/10 ; C07K16/00 ; C07K16/28 ; C12N15/10

Abstract:
The present invention relates to a novel antibody library and an antibody-screening method using same. Having a human sequence-derived specific VH or VL scaffold, the antibody library according to the present invention exhibits high thermodynamic stability and enjoys the advantages of allowing high soluble expression as well as reversible folding. In addition, the antibody according to the present invention includes a variety of rationally controlled CDRs so as to exhibit high specificity and high affinity to all antigens and thus can be advantageously used for selecting an adequate candidate antibody against a target antigen.
Public/Granted literature
- US20220275360A1 ANTIBODY LIBRARY AND ANTIBODY SCREENING METHOD USING SAME Public/Granted day:2022-09-01
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