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公开(公告)号：US10851175B2
公开(公告)日：2020-12-01
申请号：US15762885
申请日：2016-09-23
Inventor： Dong-Sik Kim , Eun Jung Song , Mijung Lee , Eun-Hee Lee , Miyoung Oh , Jae Chan Park , Kisu Kim , Sujeong Kim , Hyung-Kwon Lim , Kyuhyun Lee , Jongwha Won , Soongyu Choi , Young Seoub Park
Abstract: The present invention relates to an antibody specifically bound to mesothelin (MSLN), a nucleic acid encoding the antibody, a vector and a host cell including the nucleic acid, a method for producing the antibody, and a pharmaceutical composition for treating cancer or tumor including the antibody as an active ingredient. The antibody specifically bound to the mesothelin according to the present invention has high affinity and specificity to an antigen, such that it is possible to develop an antibody effectively usable for treatment or diagnosis of cancer or tumor diseases.
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公开(公告)号：US12071710B2
公开(公告)日：2024-08-27
申请号：US17058124
申请日：2019-05-31
Applicant: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
Inventor： Dong-Sik Kim , Mi Jung Lee , Mi Young Oh , Hye-Ji Choi , Gil-Jung Kim , Shin A Jang , Ae Rin Yoon
CPC classification number: C40B40/10 , C07K16/005 , C07K16/28 , C12N15/1037 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/94
Abstract: The present invention relates to a novel antibody library and an antibody-screening method using same. Having a human sequence-derived specific VH or VL scaffold, the antibody library according to the present invention exhibits high thermodynamic stability and enjoys the advantages of allowing high soluble expression as well as reversible folding. In addition, the antibody according to the present invention includes a variety of rationally controlled CDRs so as to exhibit high specificity and high affinity to all antigens and thus can be advantageously used for selecting an adequate candidate antibody against a target antigen.
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公开(公告)号：US10752697B2
公开(公告)日：2020-08-25
申请号：US15771527
申请日：2016-10-27
Applicant: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
Inventor： Jae Chan Park , Kisu Kim , Mijung Lee , Eun-Hee Lee , Dong-Sik Kim , Eun Jung Song , Sujeong Kim , Hyung-Kwon Lim , Kyuhyun Lee , Jongwha Won , Soongyu Choi , Young Seoub Park
Abstract: The present invention relates to an antibody specifically binding to glypican 3 (GPC3), a nucleic acid encoding the antibody, a vector and a host cell containing the nucleic acid, a method of preparing the antibody, and a pharmaceutical composition for treating cancer or tumor, containing the antibody as an active ingredient. The antibody specifically binding to glypican 3 according to the present invention may be effectively used to treat cancer or tumor, particularly, hepatocellular carcinoma due to high affinity and specificity to glypican 3.
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公开(公告)号：US10266607B2
公开(公告)日：2019-04-23
申请号：US15553292
申请日：2015-12-29
Applicant: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
Inventor： Dong-Sik Kim , Mi Jung Lee , Jae Chan Park , Sumin Lee , Heechun Kwak , SungHo Hwang , Hyung-Kwon Lim , Kisu Kim , Young Seoub Park , Junhong Jeong , Ki Joon Cho
IPC: C07K16/38
Abstract: The present invention relates to an antibody that binds specifically to a tissue factor pathway inhibitor (TFPI), a nucleic acid encoding the antibody, a vector comprising the nucleic acid, a host cell transformed with the vector, a method for producing the antibody, and a pharmaceutical composition for treating hemophilia, which comprises the antibody as an active ingredient. The antibody of the present invention, which binds specifically to TFPI, can activate the extrinsic pathway of blood coagulation by inhibiting TFPI. Thus, the antibody of the present invention can be effectively used for the treatment of antibody-induced hemophilia patients and for the prevention of blood coagulation disease in hemophilia-A or hemophilia-B patients.
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