- 专利标题： Antibodies of the class IGG4
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申请号： US16717671申请日： 2019-12-17
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公开(公告)号： US12091450B2公开(公告)日： 2024-09-17
- 发明人: David Paul Humphreys , Ralph Adams , James Heads , Shirley Jane Peters
- 申请人： UCB PHARMA S.A.
- 申请人地址： BE Brussels
- 专利权人： UCB BIOPHARMA SRL
- 当前专利权人： UCB BIOPHARMA SRL
- 当前专利权人地址： BE Brussels
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 优先权： GB 14033 2010.08.20
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; A61K39/395 ; C07K16/24 ; C12P21/08
摘要：
The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.
公开/授权文献
- US20200157204A1 Antibodies of the Class IGG4 公开/授权日：2020-05-21
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