公开(公告)号：US12091450B2

公开(公告)日：2024-09-17

申请号：US16717671

申请日：2019-12-17

申请人： UCB PHARMA S.A.

发明人： David Paul Humphreys ,  Ralph Adams ,  James Heads ,  Shirley Jane Peters

IPC分类号： C07K16/00 ,  A61K39/395 ,  C07K16/24 ,  C12P21/08

CPC分类号： C07K16/24 ,  A61K39/39591 ,  C07K16/00 ,  C07K2317/40 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/53 ,  C07K2317/94

摘要： The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.

公开(公告)号：US20200157204A1

公开(公告)日：2020-05-21

申请号：US16717671

申请日：2019-12-17

申请人： UCB PHARMA S.A.

发明人： David Paul Humphreys ,  Ralph Adams ,  James Heads ,  Shirley Jane Peters

IPC分类号： C07K16/24 ,  A61K39/395 ,  C07K16/00

摘要： The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.