A physical simulation test system for studying a tunnel structure under active fault movements includes: a simulation box, a loading frame, a first loading mechanism, a second loading mechanism and a third loading mechanism. The simulation box is a hollow and open box structure including a first box and a second box that can slide relative to each other. The loading frame includes a crossbeam, a first bracket, a second bracket, and a third bracket. The simulation box is located below the crossbeam, between the first bracket and the second bracket, and in front of the third bracket. The first loading mechanism is disposed on the first bracket, the second loading mechanism is located below the first box, and the third loading mechanism is disposed on the third bracket. The three loading mechanisms are configured to provide loading forces in three different directions to the first box.