Invention Grant
- Patent Title: Antibodies specific for hyperphosphorylated tau and methods of use thereof
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Application No.: US17399205Application Date: 2021-08-11
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Publication No.: US12129289B2Publication Date: 2024-10-29
- Inventor: Jan Torleif Pedersen , Kristian Kjaergaard , Lars Østergaard Pedersen , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Alfred Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: DK 201600416 2016.07.12 DK 201700005 2017.01.04 DK 201700008 2017.01.04 DK 201700179 2017.03.14
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K39/395 ; A61K49/00 ; G01N33/68 ; A61K39/00
Abstract:
The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
Public/Granted literature
- US20220177557A1 ANTIBODIES SPECIFIC FOR HYPERPHOSPHORYLATED TAU AND METHODS OF USE THEREOF Public/Granted day:2022-06-09
Information query
