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公开(公告)号：US20190330320A1
公开(公告)日：2019-10-31
申请号：US16475299
申请日：2018-01-03
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Daechsel , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist
Abstract: The present invention is based on antibodies which are both highly specific for hyperphosphorylated pathogenic P-S396 tau and highly specific for labelled sections of the human retina, as well as to methods of using these antibodies and their tau binding fragments in the treatment of retinoid amyloidosis, age related macular degeneration (ARMD), and glaucoma.
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公开(公告)号：US12129289B2
公开(公告)日：2024-10-29
申请号：US17399205
申请日：2021-08-11
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Kristian Kjaergaard , Lars Østergaard Pedersen , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Alfred Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
IPC: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/68 , A61K39/00
CPC classification number: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/6896 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2800/2814 , G01N2800/2821
Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
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Patent Agency Ranking
公开(公告)号：US10995137B2
公开(公告)日：2021-05-04
申请号：US16475299
申请日：2018-01-03
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Daechsel , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist
Abstract: The present invention is based on antibodies which are both highly specific for hyperphosphorylated pathogenic P-S396 tau and highly specific for labelled sections of the human retina, as well as to methods of using these antibodies and their tau binding fragments in the treatment of retinoid amyloidosis, age related macular degeneration (ARMD), and glaucoma.
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公开(公告)号：US10196439B2
公开(公告)日：2019-02-05
申请号：US15207836
申请日：2016-07-12
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Alfred Daechsel , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Christiane Volbracht , Lone Helboe , Anders Brandt Elvang , Florence Sotty , Søren Christensen , Jeffrey B. Stavenhagen
IPC: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/68 , A61K39/00
Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
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公开(公告)号：US20220177557A1
公开(公告)日：2022-06-09
申请号：US17399205
申请日：2021-08-11
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Kristian Kjaergaard , Lars Østergaard Pedersen , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Alfred Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
IPC: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/68
Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PH F) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
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公开(公告)号：US11111290B2
公开(公告)日：2021-09-07
申请号：US16585207
申请日：2019-09-27
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Kristian Kjaergaard , Lars Østergaard Pedersen , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Alfred Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
IPC: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/68 , A61K39/00
Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
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7.发明申请Antibodies Specific for Hyperphosphorylated Tau and Methods of Use Thereof 审中-公开特异于超磷酸化Tau的抗体及其使用方法公开(公告)号：US20170015738A1
公开(公告)日：2017-01-19
申请号：US15207836
申请日：2016-07-12
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Alfred Daechsel , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist
CPC classification number: C07K16/18 , A61K39/395 , A61K49/00 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
Abstract translation: 本发明涉及特异性结合磷酸化丝氨酸396残基的病毒性高磷酸化（PHS）tau（pS396）的新型单克隆抗体，以及在治疗阿尔茨海默氏病中使用这些分子及其tau结合片段的方法 和tau蛋白病。
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