An application specific integrated circuit (ASIC) is provided for reliable transport of packets. The network interface card may include a reliable transport accelerator (RTA). The RTA may include a cache lookup database. The RTA may be configured to determine, from a received data packet, a connection identifier and query the cache lookup database for a cache entry corresponding to a connection context having the connection identifier. In response to the query, the RTA may receive a cache hit or a cache miss.