A fast clock domain crossing architecture for high frequency trading includes a receiver that recovers data and a clock of a first clock domain from a communication from an exchange, functional circuitry that generates and a buy/sell command based on the recovered data and the recovered clock, format circuitry that formats the command in a second clock domain, and a transmitter that transmits the formatted command to the exchange. The architecture further includes error detection circuitry that detects bit errors that arise from an asynchronous boundary of the clock domains without increasing a round-trip latency, and/or synchronization circuitry that synchronizes the clock domains, where the synchronization circuitry includes a cleanup PLL that filters input jitter and a phase detector and variable delay line that compensate for latency within the architecture.