Invention Grant
- Patent Title: Chimeric antigen receptors targeting CD70
-
Application No.: US17843616Application Date: 2022-06-17
-
Publication No.: US12152081B2Publication Date: 2024-11-26
- Inventor: Surabhi Srivatsa Srinivasan , Niranjana Nagarajan , Siler Panowski , Yoon Park , Tao Sai , Barbra Sasu , Thomas Van Blarcom , Mathilde Dusseaux , Roman Galetto
- Applicant: Pfizer Inc.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/00 ; A61P35/02 ; A61P35/04 ; C07K14/725

Abstract:
The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).
Public/Granted literature
- US20230041456A1 CHIMERIC ANTIGEN RECEPTORS TARGETING CD70 Public/Granted day:2023-02-09
Information query