公开(公告)号：US12152081B2

公开(公告)日：2024-11-26

申请号：US17843616

申请日：2022-06-17

Applicant: Pfizer Inc.

Inventor： Surabhi Srivatsa Srinivasan ,  Niranjana Nagarajan ,  Siler Panowski ,  Yoon Park ,  Tao Sai ,  Barbra Sasu ,  Thomas Van Blarcom ,  Mathilde Dusseaux ,  Roman Galetto

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/02 ,  A61P35/04 ,  C07K14/725

Abstract: The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).