The present disclosure provides an electric motor control system and a vehicle. The electric motor control system includes a motor drive module, a multi-core processing module, and a safety logic module. The multi-core processing module includes a main function core and a lockstep monitoring core. The main function core is configured to obtain sampling data, and when any one of the sampling data, a running status of the main function core, a motor control signal, and a running status of a motor is abnormal, the lockstep monitoring core outputs a safety trigger signal; and the safety logic module is configured to output an instruction for prohibiting execution of the motor control signal to the motor drive module when receiving the safety trigger signal.