Invention Grant
- Patent Title: 4-amino or 4-alkoxy-substituted aryl sulfonamide compounds with selective activity in voltage-gated sodium channels
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Application No.: US17296601Application Date: 2019-12-02
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Publication No.: US12246008B2Publication Date: 2025-03-11
- Inventor: Christopher J. Bungard , Helen Y. Chen , Jason M. Cox , Liangqin Guo , Michael J. Kelly, III , Ronald M. Kim , Mark E. Layton , Hong Liu , Jian Liu , Mehul F. Patel , James J. Perkins , Deping Wang , Walter Won , Younong Yu , Ting Zhang
- Applicant: Merck Sharp & Dohme LLC
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme LLC
- Current Assignee: Merck Sharp & Dohme LLC
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; Catherine D. Fitch
- International Application: PCT/US2019/063909 WO 20191202
- International Announcement: WO2020/117626 WO 20200611
- Main IPC: A61K31/433
- IPC: A61K31/433 ; A61K31/167 ; A61K31/4439 ; A61K31/505 ; A61K31/5377 ; C07D239/42 ; C07D285/08 ; C07D417/12
Abstract:
Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.
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