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公开(公告)号：US12091405B2
公开(公告)日：2024-09-17
申请号：US17287256
申请日：2019-10-28
发明人： Dane Clausen , Xavier Fradera , Liangqin Guo , Yongxin Han , Shuwen He , Joseph Kozlowski , Guoqing Li , Theodore A. Martinot , Alexander Pasternak , David Sloman , Li Xiao , Wensheng Yu , Rui Zhang
IPC分类号： C07D413/14 , C07D401/14
CPC分类号： C07D413/14 , C07D401/14
摘要： Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号：US11484565B2
公开(公告)日：2022-11-01
申请号：US17005686
申请日：2020-08-28
发明人： Hubert Josien , Abbas Walji , Harold B. Wood , Fa-Xiang Ding , Jian Liu , Thomas Joseph Tucker , Michael Man-Chu Lo , Liangqin Guo
摘要： Disclosed are compounds of Formula A, or a pharmaceutically acceptable salt thereof: where A, X, R1, and R2 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.
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公开(公告)号：US12065438B2
公开(公告)日：2024-08-20
申请号：US17289062
申请日：2019-11-01
发明人： Yongxin Han , David Jonathan Bennett , Indu Bharathan , Liangqin Guo , Brett A. Hopkins , Xianhai Huang , Derun Li , Min Lu , Alexander Pasternak , David L. Sloman , Hongjun Zhang , Hua Zhou
IPC分类号： C07D471/04 , C07D209/94 , C07D215/14 , C07D401/04 , C07D403/04
CPC分类号： C07D471/04 , C07D209/94 , C07D215/14 , C07D401/04 , C07D403/04
摘要： Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Formula (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号：US20230165932A1
公开(公告)日：2023-06-01
申请号：US18051250
申请日：2022-10-31
发明人： Hubert Josien , Abbas Walji , Harold B. WOOD , Fa-Xiang Ding , Jian Liu , Thomas Joseph Tucker , Michael Man-Chu Lo , Liangqin Guo
摘要： Disclosed are compounds of Formula A, or a pharmaceutically acceptable salt thereof:
where A, X, R1, and R2 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.-
公开(公告)号：US20240018145A1
公开(公告)日：2024-01-18
申请号：US18015465
申请日：2021-07-22
发明人： Yonglian Zhang , John A. McCauley , Michael Man-Chu Lo , Liangqin Guo , Kake Zhao , Frank Bennett , Ronald M. Kim , Reynalda Keh DeJesus , Valerie W. Shurtleff , Manuel de Lera Ruiz , Michael Plotkin , Hua Su , James Fells , Brendan M. Crowley , Harry R. Chobanian , Mark W. Embrey , Gregori J. Morriello
IPC分类号： C07D471/14 , C07D491/22 , C07D471/04 , A61P31/16
CPC分类号： C07D471/14 , A61P31/16 , C07D471/04 , C07D491/22
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing influenza. The compounds are cap-dependent endonuclease inhibitors.
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