Invention Grant
- Patent Title: Pairing antigen specificity of a T cell with T cell receptor sequences
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Application No.: US16492588Application Date: 2018-03-08
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Publication No.: US12258613B2Publication Date: 2025-03-25
- Inventor: James R. Heath , Songming Peng , Alphonsus Hon-Chung Ng
- Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Applicant Address: US CA Pasadena
- Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee Address: US CA Pasadena
- Agency: KNOBBE, MARTENS, OLSON & BEAR, LLP
- International Application: PCT/US2018/021611 WO 20180308
- International Announcement: WO2018/165475 WO 20180913
- Main IPC: C12Q1/6804
- IPC: C12Q1/6804 ; B01L3/00 ; C12N15/10
Abstract:
Compositions and methods for identifying antigen-specific T cells, including determining paired T cell receptor sequences for a specific antigen, are described. Compositions and methods for identifying neoantigen-specific T cells are also described. Microfluidic devices useful for identifying antigen-specific T cells, and methods of using the same, are also described.
Public/Granted literature
- US20230069843A1 PAIRING ANTIGEN SPECIFICITY OF A T CELL WITH T CELL RECEPTOR SEQUENCES Public/Granted day:2023-03-09
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