Invention Grant
- Patent Title: Antibody comprising a glutamine-containing light chain C-terminal extension, conjugates thereof, and methods and uses
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Application No.: US17297796Application Date: 2019-11-25
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Publication No.: US12290570B2Publication Date: 2025-05-06
- Inventor: Pavel Strop , Chetana Rao-Naik , Xiaodi Deng , Paul O. Sheppard , Patrick G. Holder , Sayumi Yamazoe
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Gregory R. Bellomy
- International Application: PCT/US2019/062913 WO 20191125
- International Announcement: WO2020/112588 WO 20200604
- Main IPC: A61K47/68
- IPC: A61K47/68 ; C07K16/18
Abstract:
An antibody has a glutamine-containing extension at the C-terminus of a light chain thereof, making it suitable for conjugation via transglutaminase-mediated transamidation.
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