发明申请
US20020182717A1 Method of preparing supported lipid film membranes and use thereof
审中-公开
制备支持脂质膜的方法及其应用
- 专利标题： Method of preparing supported lipid film membranes and use thereof
- 专利标题（中）： 制备支持脂质膜的方法及其应用
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申请号： US10098739申请日： 2002-03-14
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公开(公告)号： US20020182717A1公开(公告)日： 2002-12-05
- 发明人: Olof Karlsson
- 申请人： Biacore AB
- 申请人地址： SE Uppsala
- 专利权人： Biacore AB
- 当前专利权人： Biacore AB
- 当前专利权人地址： SE Uppsala
- 优先权： SE0100875-4 20010314
- 主分类号： G01N033/542
- IPC分类号： G01N033/542 ; B05D003/00 ; C12M001/34 ; G01N033/53
摘要：
The present invention relates to a method of preparing a substrate surface supporting a lipid film membrane structure, which method comprises the steps of contacting a substrate surface with an aqueous liquid containing detergent/lipid mixed micelles to adhere detergent/lipid mixed micelles to the substrate surface, and then contacting the substrate surface having detergent/lipid mixed micelles adhered thereto with an aqueous liquid substantially free from detergent to elute the detergent molecules from the adhered mixed micelles and make the remaining lipid molecules assemble into a lipid film membrane structure on the substrate surface. The invention also relates to a substrate supporting a lipid film membrane structure as prepared by the method, the use of a substrate supporting a lipid film membrane structure as prepared by the method for molecular interaction studies, and a substrate surface for use in the method.
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