发明申请
US20030138419A1 Recombinant antibody fusion proteins and methods for detection of apoptotic cells
审中-公开
重组抗体融合蛋白和检测凋亡细胞的方法
- 专利标题： Recombinant antibody fusion proteins and methods for detection of apoptotic cells
- 专利标题（中）： 重组抗体融合蛋白和检测凋亡细胞的方法
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申请号： US10295757申请日： 2002-11-15
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公开(公告)号： US20030138419A1公开(公告)日： 2003-07-24
- 发明人: Marko Z. Radic , Brian A. Cocca
- 申请人： The University of Tennessee Research Corporation
- 申请人地址： null
- 专利权人： The University of Tennessee Research Corporation
- 当前专利权人： The University of Tennessee Research Corporation
- 当前专利权人地址： null
- 主分类号： A61K039/395
- IPC分类号： A61K039/395 ; C07K016/30
摘要：
Recombinant antibody single chain variable fragments (scFv) useful for detecting apoptotic cells are disclosed. The antibodies selectively bind on the surface of apoptotic cells. Methods of generating and employing the antibodies are also provided. Methods of detecting modulation of apoptosis are disclosed. Methods of evaluating the efficacy of a candidate therapeutic compound adapted to effect a change in apoptosis are also disclosed. Additionally, a kit for the detection of apoptotic cells is also disclosed.
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