公开(公告)号：US20030138419A1

公开(公告)日：2003-07-24

申请号：US10295757

申请日：2002-11-15

申请人： The University of Tennessee Research Corporation

发明人： Marko Z. Radic ,  Brian A. Cocca

IPC分类号： A61K039/395 ,  C07K016/30

CPC分类号： C07K16/28 ,  C07K2317/622

摘要： Recombinant antibody single chain variable fragments (scFv) useful for detecting apoptotic cells are disclosed. The antibodies selectively bind on the surface of apoptotic cells. Methods of generating and employing the antibodies are also provided. Methods of detecting modulation of apoptosis are disclosed. Methods of evaluating the efficacy of a candidate therapeutic compound adapted to effect a change in apoptosis are also disclosed. Additionally, a kit for the detection of apoptotic cells is also disclosed.

摘要翻译： 公开了可用于检测凋亡细胞的重组抗体单链可变片段（scFv）。 抗体选择性结合凋亡细胞的表面。 还提供产生和使用抗体的方法。 公开了检测凋亡调节的方法。 还公开了评估适于影响凋亡变化的候选治疗化合物的功效的方法。 此外，还公开了用于检测凋亡细胞的试剂盒。