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    Antibodies against SLC15A2 and uses thereof
    1.
    发明申请
    Antibodies against SLC15A2 and uses thereof 审中-公开
    针对SLC15A2的抗体及其用途

    公开(公告)号：US20040223970A1

    公开(公告)日：2004-11-11

    申请号：US10789090

    申请日：2004-02-27

    发明人： Daniel Afar ,  Debbie Law

    IPC分类号： A61K039/395 ,  C07K016/30

    CPC分类号： C07K16/3069 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/77 ,  G01N33/57484

    摘要： The invention relates to the identification and generation of antibodies that specifically bind to SLC15A2 protein. The disclosed anti-SLC15A2 antibodies and compositions comprising them may be used for diagnosis, prognosis and therapy of cancer (including metastatic cancer) or fibrotic conditions, e.g., ovarian cancer, cervical cancer, prostate cancer, uterine cancer, lung cancer, lung fibrosis, and glioblastoma. The disclosed antibodies include conjugates with cytotoxic effector components that are useful for cancer therapy.

    摘要翻译： 本发明涉及特异性结合SLC15A2蛋白的抗体的鉴定和产生。 所公开的抗SLC15A2抗体及其组合物可用于诊断，预后和治疗癌症（包括转移性癌症）或纤维化病症，例如卵巢癌，子宫颈癌，前列腺癌，子宫癌，肺癌，肺纤维化， 和胶质母细胞瘤。 所公开的抗体包括可用于癌症治疗的具有细胞毒性效应子组分的缀合物。

    Method for detection of carcinoembryonic antigens having a modified sugar chain structure
    2.
    发明申请
    Method for detection of carcinoembryonic antigens having a modified sugar chain structure 审中-公开
    检测具有修饰的糖链结构的癌胚抗原的方法

    公开(公告)号：US20040185512A1

    公开(公告)日：2004-09-23

    申请号：US10767718

    申请日：2004-01-30

    申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD.

    发明人： Hideaki Hosokawa ,  Kenji Nakamura ,  Shinji Satomura

    IPC分类号： G01N033/574 ,  C07K016/30

    CPC分类号： G01N33/57473 ,  G01N2400/02

    摘要： The present invention relates to a method for detection of carcinoembryonic antigens (hereinafter abbreviated as CEAs) having a modified sugar chain structure which comprises using an antibody against a constant region of CEAs and a protein capable of recognizing a modified sugar chain structure of CEAs, a method for detecting a cancer which comprises using an amount of CEAs having a modified sugar chain structure and a kit for detection of CEAs having a modified sugar chain structure which comprises an antibody against a constant region of CEAs and a protein capable of recognizing a modified sugar chain structure of CEAs. Said method and kit are useful in a separately measurement of the various CEAs, a detection of a cancer and a definition of the kind of a cancer, and, for example, by using in proper combination of the measurement value of various CEAs obtained by the method of the present invention, it becomes possible to detect the cancer or define the kind of the cancer.

    摘要翻译： 本发明涉及一种检测具有修饰的糖链结构的癌胚抗原（以下简称为CEA）的方法，其包括使用针对恒定区的CEA的抗体和能够识别CEA的修饰的糖链结构的蛋白质， 用于检测癌症的方法，其包括使用一定量的具有修饰的糖链结构的CEA和用于检测具有修饰的糖链结构的CEA的试剂盒，其包含针对恒定区的CEA的抗体和能够识别修饰的糖的蛋白质 CEAs的链结构。 所述方法和试剂盒可用于各种CEA的单独测量，癌症的检测和癌症种类的定义，并且例如通过以下方式适当地组合各种CEAs的测量值： 本发明的方法，可以检测癌症或确定癌症的种类。

    Immunoassays for specific determination of SCCA isoforms
    3.
    发明申请
    Immunoassays for specific determination of SCCA isoforms 审中-公开
    用于特异性测定SCCA同种型的免疫测定

    公开(公告)号：US20040176577A1

    公开(公告)日：2004-09-09

    申请号：US10652705

    申请日：2003-08-29

    发明人： Eva Rojer ,  Olle Nilsson

    IPC分类号： C07K016/30 ,  A61K039/395 ,  G01N033/574

    CPC分类号： C07K16/30 ,  G01N33/57484

    摘要： The present invention relates to monoclonal antibodies capable of distinguishing squamous cell cancer antigens, SCCA, in either free or complex bound forms, preferably antigens SCCA1 and SCCA2, as well as hybridomas recognizing such antibodies, method for diagnosing SCC, as well as diagnostic kits for detecting SCCAs.

    摘要翻译： 本发明涉及能够区分游离或复合结合形式的鳞状细胞癌抗原SCCA的单克隆抗体，优选抗原SCCA1和SCCA2，以及识别这种抗体的杂交瘤，用于诊断SCC的诊断试剂盒 检测SCCAs。

    Angiogenesis related molecules
    6.
    发明申请
    Angiogenesis related molecules 审中-公开
    血管生成相关分子

    公开(公告)号：US20040141978A1

    公开(公告)日：2004-07-22

    申请号：US10720273

    申请日：2003-11-25

    申请人： PHARMACIA & UPJOHN AB

    发明人： Lars Holmgren ,  Boris Troyanovsky

    IPC分类号： A61K039/395 ,  C07K016/30

    CPC分类号： C07K14/71 ,  A61K38/00

    摘要： The present invention provides the sequence of a protein capable of acting as an angiostatin receptor as well as the nucleic acid sequence thereof. The invention also relates to the use thereof in screening methods, wherein novel substances are created exhibiting the same advantageous anti-angiogenic properties as angiostatin.

    摘要翻译： 本发明提供能够作为血管抑素受体的蛋白质的序列及其核酸序列。 本发明还涉及其在筛选方法中的用途，其中产生的新物质具有与血管抑素相同的有利的抗血管生成特性。

    Methods and compositions for detecting cancers
    8.
    发明申请
    Methods and compositions for detecting cancers 审中-公开
    用于检测癌症的方法和组合物

    公开(公告)号：US20040053304A1

    公开(公告)日：2004-03-18

    申请号：US10456930

    申请日：2003-06-05

    申请人： Case Western Reserve University

    发明人： Sanford D. Markowitz

    IPC分类号： C12Q001/68 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K016/30 ,  C07K014/705

    CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0331 ,  C07K14/4702 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/154

    摘要： In certain aspects, the invention provides isolated SLC5A8 (also referred to as Hui1) nucleic acid molecules, which encode novel sodium solute symporter members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLC5A8 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLC5A8 gene has been introduced or disrupted. The invention still further provides isolated SLC5A8 proteins, fusion proteins, antigenic peptides, and anti-SLC5A8 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. In other aspects, the invention provides methods and compositions for detecting and treating SLC5A8-associated cancer. Differential methylation of the SLC5A8 nucleotide sequences has been observed in SLC5A8-associated cancer, such as colon cancer, breast cancer, thyroid cancer, or stomach cancer.

    摘要翻译： 在某些方面，本发明提供了分离的SLC5A8（也称为Hui1）核酸分子，其编码新的钠溶质对转体成员。 本发明还提供了反义核酸分子，含有SLC5A8核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏SLC5A8基因的非人转基因动物。 本发明还进一步提供了分离的SLC5A8蛋白，融合蛋白，抗原肽和抗SLC5A8抗体。 还提供了利用本发明组合物的诊断方法。 在其它方面，本发明提供了用于检测和治疗SLC5A8相关癌症的方法和组合物。 已经在SLC5A8相关癌症如结肠癌，乳腺癌，甲状腺癌或胃癌中观察到SLC5A8核苷酸序列的差异甲基化。

    ALCAM and ALCAM modulators
    9.
    发明申请
    ALCAM and ALCAM modulators 审中-公开
    ALCAM和ALCAM调制器

    公开(公告)号：US20040048319A1

    公开(公告)日：2004-03-11

    申请号：US10428983

    申请日：2003-05-02

    发明人： Jennie P. Mather ,  Ronghao Li ,  Mary C. Tsao ,  Deryk T. Loo

    IPC分类号： G01N033/574 ,  C07H021/04 ,  C07K016/30 ,  C12N005/06

    CPC分类号： C07K16/30 ,  C07K14/70503 ,  C07K2317/77 ,  Y02P20/582

    摘要： Provided herein is disclosure about the discovery that the known antigen, ALCAM, is present on a variety of human cancers other than metastasizing malignant melanoma. Also disclosed herein are methods of diagnosing and treating cancers that express ALCAM by using antibodies directed against ALCAM. This invention also discloses compositions and methods for the modulation of ALCAM-mediated neovascularization.

    摘要翻译： 本文提供了关于已知抗原ALCAM存在于转移恶性黑素瘤以外的各种人类癌症的发现的公开。 本文还公开了通过使用针对ALCAM的抗体来诊断和治疗表达ALCAM的癌症的方法。 本发明还公开了调节ALCAM介导的新生血管形成的组合物和方法。