- 专利标题： Polymer stabilized neuropeptides
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申请号： US10354683申请日： 2003-01-30
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公开(公告)号： US20030144207A1公开(公告)日： 2003-07-31
- 发明人: Michael David Bentley , Michael James Roberts
- 申请人： Shearwater Corporation
- 申请人地址： null
- 专利权人： Shearwater Corporation
- 当前专利权人： Shearwater Corporation
- 当前专利权人地址： null
- 主分类号： C07K014/70
- IPC分类号： C07K014/70 ; A61K038/24
摘要：
A substantially hydrophilic conjugate is provided having a peptide that is capable of passing the blood-brain barrier covalently linked to a water-soluble nonpeptidic polymer such as polyethylene glycol. The conjugate exhibits improved solubility and in vivo stability and is capable of passing the blood-brain barrier of an animal.
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