公开(公告)号：US20030144207A1

公开(公告)日：2003-07-31

申请号：US10354683

申请日：2003-01-30

申请人： Shearwater Corporation

发明人： Michael David Bentley ,  Michael James Roberts

IPC分类号： C07K014/70 ,  A61K038/24

CPC分类号： A61K47/60

摘要： A substantially hydrophilic conjugate is provided having a peptide that is capable of passing the blood-brain barrier covalently linked to a water-soluble nonpeptidic polymer such as polyethylene glycol. The conjugate exhibits improved solubility and in vivo stability and is capable of passing the blood-brain barrier of an animal.

公开(公告)号：US20020019519A1

公开(公告)日：2002-02-14

申请号：US09871916

申请日：2001-06-01

发明人： Sharon Bingham ,  Patrick Case ,  Sally Neale Lawson ,  Richard Anthony Newton ,  Oliver Lars Rausch ,  Alastair David Reith ,  Gareth John Sanger

IPC分类号： C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K014/70

CPC分类号： C12N9/1205 ,  A61K39/00 ,  A61K48/00

摘要： The use of KIAA0551 polypeptides and polynucleotides in the design of protocols for the treatment of neuropathies, neuropathic pain, inflammatory and chronic pain, neurodegenerative conditions such as Motor Neuron Disease, Parkinson's Disease, Alzheimer's Disease and other dementias, as well as ischaemic damage in neuronal and cardiac tissues, through disease or infectious agents, among others, and diagnostic assays for such conditions. Also disclosed are methods for producing such polypeptides by recombinant techniques.

摘要翻译： 在设计用于治疗神经病，神经性疼痛，炎性和慢性疼痛，神经变性疾病如运动神经元疾病，帕金森病，阿尔茨海默病和其他痴呆症的方案中使用KIAA0551多肽和多核苷酸以及神经元中的缺血性损伤 和心脏组织，通过疾病或感染因子等，以及这些病症的诊断测定。 还公开了通过重组技术产生这种多肽的方法。