发明申请
- 专利标题: High-throughput tissue microarray technology and applications
- 专利标题(中): 高通量组织微阵列技术及应用
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申请号: US10149520申请日: 2003-04-14
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公开(公告)号: US20030215936A1公开(公告)日: 2003-11-20
- 发明人: Olli Kallioniemi , Guido Sauter , Stephen B. Leighton , Juha Kononen , Thomas J. Pohida , John William Karareka , Ghadi Hamdi Salem
- 主分类号: C12M001/34
- IPC分类号: C12M001/34 ; G01N001/30 ; G01N033/48
摘要:
A method and apparatus are disclosed for a high-throughput, large-scale molecular profiling of tissue specimens by retrieving a donor tissue specimen from an array of donor specimens, placing a sample of the donor specimen in an assigned location in a recipient array, providing substantial copies of the array, performing a different biological analysis of each copy, and storing the results of the analysis. The results may be compared to determine if there are correlations or discrepancies between the results of different biological analyses at each assigned location, and also compared to clinical information about the human patient from which the tissue was obtained. The results of similar analyses on corresponding sections of the array can be used as quality control devices, for example by subjecting the arrays to a single simultaneous investigative procedure. Uniform interpretation of the arrays can be obtained, and compared to interpretations of different observers.
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