发明申请
US20040013646A1 Modulator of TNF/NGF superfamily receptors and soluble oligomeric TNF/NGF superfamily receptors
失效
TNF / NGF超家族受体和可溶性低聚TNF / NGF超家族受体的调节剂
- 专利标题： Modulator of TNF/NGF superfamily receptors and soluble oligomeric TNF/NGF superfamily receptors
- 专利标题（中）： TNF / NGF超家族受体和可溶性低聚TNF / NGF超家族受体的调节剂
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申请号： US10349977申请日： 2003-01-24
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公开(公告)号： US20040013646A1公开(公告)日： 2004-01-22
- 发明人: David Wallach , Mark Boldin , Igor Mett , Eugene Varfolomeev
- 申请人： Yeda Research and Development Co. Ltd.
- 申请人地址： IL Rehovot
- 专利权人： Yeda Research and Development Co. Ltd.
- 当前专利权人： Yeda Research and Development Co. Ltd.
- 当前专利权人地址： IL Rehovot
- 优先权： IL109,632 19940511; IL111,125 19941002
- 主分类号： A61K048/00
- IPC分类号： A61K048/00 ; A61K039/395 ; C07K016/30 ; C07H021/04
摘要：
The present invention generally concerns novel proteins which bind to the intracellular domains of the p55 and p75 TNF-Rs and the FAS-R, which are capable of modulating the function of the p55 and p75 TNF-Rs and the FAS-R, and the DNA sequences which encode them. The present invention also concerns new soluble oligomeric TNF-Rs, oligomeric FAS-Rs and oligomeric receptors having a mixture of TNF-Rs and FAS-Rs. In addition, the present invention concerns methods of preparation and uses of all of the aforementioned.
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