发明申请
US20040053338A1 Method of identifying calcium-binding sites in gamma-crystallin useful for management of cataract
失效
鉴定用于治疗白内障的γ-晶状体蛋白中的钙结合位点的方法
- 专利标题： Method of identifying calcium-binding sites in gamma-crystallin useful for management of cataract
- 专利标题（中）： 鉴定用于治疗白内障的γ-晶状体蛋白中的钙结合位点的方法
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申请号： US10350558申请日： 2003-01-24
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公开(公告)号： US20040053338A1公开(公告)日： 2004-03-18
- 发明人: Yogendra Sharma , Bheemreddy Rajini Devi
- 主分类号： G01N033/53
- IPC分类号： G01N033/53 ; G01N033/567 ; G01N001/30 ; G01N033/48
摘要：
The present invention relates to a method of identifying calcium binding sites in gamma-crystallin useful in calcium-based homeostasis for the management of Cataract, said method comprising steps of isolating gamma-crystallin from eye lens, studying binding of calcium to the isolated protein by both direct and indirect methods, identifying Greek key Motif as calcium-binding sites of the protein gamma crystallin with the said protein binding 4-mol eq of calcium having dissociation constant of 90micromole.
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