发明申请
US20050004165A1 Composition and method for modulating BAR/FXR receptor activity
审中-公开
用于调节BAR / FXR受体活性的组合物和方法
- 专利标题： Composition and method for modulating BAR/FXR receptor activity
- 专利标题（中）： 用于调节BAR / FXR受体活性的组合物和方法
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申请号： US10910688申请日： 2004-08-03
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公开(公告)号： US20050004165A1公开(公告)日： 2005-01-06
- 发明人: Barry Forman , Richard Beard , Isabelle Dussault , Roshantha Chandraratna
- 申请人： Barry Forman , Richard Beard , Isabelle Dussault , Roshantha Chandraratna
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/192 ; A61K31/202 ; A61K31/203 ; A61K31/695 ; A61P3/00 ; A61P35/00 ; A61P43/00 ; A61K31/41
摘要：
Methods for modulating the activity of the mammalian BAR/FXR receptor. The methods include methods of treating a hypocholesterolemic mammal comprising contacting the mammal with synthetic compounds able to modulate an activity characteristic of the BAR/FXR receptor. Other methods include a method of treating colon cancer in a mammal comprising administering a compound having a BAR/FXR antagonistic activity.
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