发明申请
- 专利标题： Inhibitors of fatty acid oxidation for prophylaxis and treatment of diseases related to mitochondrial dysfunction
- 专利标题（中）： 抑制脂肪酸氧化预防和治疗与线粒体功能障碍有关的疾病
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申请号： US10832801申请日： 2004-04-26
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公开(公告)号： US20050004173A1公开(公告)日： 2005-01-06
- 发明人: Thomas Henkel , Christoph Rehfuess
- 申请人： Thomas Henkel , Christoph Rehfuess
- 主分类号： A61K31/336
- IPC分类号： A61K31/336 ; A61K31/4025 ; A61K31/435 ; A61K31/443 ; A61K31/495
摘要：
Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Carnitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.
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