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1.发明申请Inhibitors of fatty acid oxidation for prophylaxis and treatment of diseases related to mitochondrial dysfunction 审中-公开抑制脂肪酸氧化预防和治疗与线粒体功能障碍有关的疾病公开(公告)号：US20100034796A1
公开(公告)日：2010-02-11
申请号：US12459227
申请日：2009-06-29
申请人： Thomas Henkel , Christoph Rehfuess
发明人： Thomas Henkel , Christoph Rehfuess
IPC分类号： A61K38/43 , C12Q1/02 , A61K48/00 , A61K31/4965 , A61K31/4458 , A61K31/336 , A61K31/202 , A61K31/20 , A61P25/28 , A61P25/16 , A61P19/00 , A61P25/00
CPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495
摘要： Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Carnitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.
摘要翻译： 描述了通过抑制生物体的一个或多个细胞的脂肪酸氧化来预防和/或治疗与线粒体功能障碍有关的疾病的方法和组合物。 特别地，通过芳基烷基 - 或芳氧基烷基取代的环氧乙烷羧酸或其药学上可接受的盐和衍生物抑制肉碱 - 棕榈酰转移酶-1（CPT-1）的表达和/或活性来抑制脂肪酸氧化 的芳基烷基取代的环氧乙烷羧酸。
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2.发明申请Inhibitors of Fatty Acid Oxidation for Prophylaxis and Treatment of Diseases Related to Mitochondrial Dysfunction 审中-公开脂肪酸氧化抑制剂用于预防和治疗与线粒体功能障碍有关的疾病公开(公告)号：US20110212072A1
公开(公告)日：2011-09-01
申请号：US13089979
申请日：2011-04-19
申请人： Thomas Henkel , Christoph Rehfuess
发明人： Thomas Henkel , Christoph Rehfuess
IPC分类号： A61K38/44 , A61K31/7088 , A61K38/46 , A61K38/51 , A61K38/43 , A61P25/28 , A61P25/16 , A61P29/00 , A61P9/10 , A61P25/18 , A61P25/08 , A61P25/06 , A61P5/18 , C12Q1/02 , C12Q1/37 , G01N33/53 , A61K31/4458 , C07D303/40 , A61K31/336 , C12Q1/68 , C07D211/12 , C07D295/096 , A61K31/495 , C07C229/34 , A61K31/198 , C07C57/03 , A61K31/202 , C07C309/47 , A61K31/185
CPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495
摘要： Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Camitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.
摘要翻译： 描述了通过抑制生物体的一个或多个细胞的脂肪酸氧化来预防和/或治疗与线粒体功能障碍有关的疾病的方法和组合物。 特别地，通过芳基烷基 - 或芳氧基烷基取代的环氧乙烷羧酸或其药学上可接受的盐和衍生物抑制羧甲基 - 棕榈酰转移酶-1（CPT-1）的表达和/或活性来抑制脂肪酸氧化 的芳基烷基取代的环氧乙烷羧酸。
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3.发明申请Inhibitors of fatty acid oxidation for prophylaxis and treatment of diseases related to mitochondrial dysfunction 审中-公开抑制脂肪酸氧化预防和治疗与线粒体功能障碍有关的疾病公开(公告)号：US20050004173A1
公开(公告)日：2005-01-06
申请号：US10832801
申请日：2004-04-26
申请人： Thomas Henkel , Christoph Rehfuess
发明人： Thomas Henkel , Christoph Rehfuess
IPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495
CPC分类号： A61K31/336 , A61K31/4025 , A61K31/435 , A61K31/443 , A61K31/495
摘要： Described are a method and a composition for preventing and/or treating a disease related to mitochondrial dysfunction by inhibiting the fatty acid oxidation of one or more cells of an organism. Particularly, the fatty acid oxidation is inhibited by inhibiting the expression and/or activity of the enzyme Carnitin-Palmitoyl-Transferase-1 (CPT-1) by means of an arylalkyl- or arlyoxyalkyl-substitued oxirane carboxylic acid or pharmaceutically acceptable salts and derivatives of the arylalkyl-substituted oxirane carboxylic acid.
摘要翻译： 描述了通过抑制生物体的一个或多个细胞的脂肪酸氧化来预防和/或治疗与线粒体功能障碍有关的疾病的方法和组合物。 特别地，通过芳基烷基 - 或芳氧基烷基取代的环氧乙烷羧酸或其药学上可接受的盐和衍生物抑制肉碱 - 棕榈酰转移酶-1（CPT-1）的表达和/或活性来抑制脂肪酸氧化 的芳基烷基取代的环氧乙烷羧酸。
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公开(公告)号：US09821043B2
公开(公告)日：2017-11-21
申请号：US14344783
申请日：2012-09-14
IPC分类号： A61K39/23 , A61K39/385 , C12N7/00 , C12P21/00 , C07K14/71 , C07K14/435 , C07K14/015 , A61K39/00 , C07K14/005 , A61K39/39
CPC分类号： A61K39/0011 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/55561 , A61K2039/55572 , A61K2039/575 , A61K2039/6075 , A61K2039/645 , C07K14/005 , C07K14/71 , C07K2319/00 , C07K2319/735 , C12N7/00 , C12N2750/14022 , C12N2750/14023 , C12N2750/14122 , C12N2750/14123 , C12P21/00 , Y10T428/2984
摘要： The present invention relates to parvovirus mutated structural proteins comprising insertions of mimotopes of a HER2, compositions, multimeric structures, medicaments and vaccines comprising the same, nucleic acids, expression cassettes, constructs, vectors and cells comprising the nucleic acids, methods of preparing the structural proteins and methods of inducing a B-cell response or of treating a HER2-related disease.
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公开(公告)号：US20150238585A1
公开(公告)日：2015-08-27
申请号：US14344783
申请日：2012-09-14
CPC分类号： A61K39/0011 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/55561 , A61K2039/55572 , A61K2039/575 , A61K2039/6075 , A61K2039/645 , C07K14/005 , C07K14/71 , C07K2319/00 , C07K2319/735 , C12N7/00 , C12N2750/14022 , C12N2750/14023 , C12N2750/14122 , C12N2750/14123 , C12P21/00 , Y10T428/2984
摘要： The present invention relates to parvovirus mutated structural proteins comprising insertions of mimotopes of a HER2, compositions, multimeric structures, medicaments and vaccines comprising the same, nucleic acids, expression cassettes, constructs, vectors and cells comprising the nucleic acids, methods of preparing the structural proteins and methods of inducing a B-cell response or of treating a HER2-related disease.
摘要翻译： 本发明涉及细小病毒突变的结构蛋白，其包括HER2的模拟表位的插入，组合物，多聚体结构，包含其的药物和疫苗，核酸，表达盒，构建体，载体和包含核酸的细胞，制备结构 诱导B细胞应答或治疗HER2相关疾病的蛋白质和方法。
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6.发明申请Topical use of cytokines and chemokines for the treatment of viral or mykotic skin diseases or tumoral diseases 审中-公开细胞因子和趋化因子的局部用途用于治疗病毒性或肌肉病性皮肤病或肿瘤性疾病公开(公告)号：US20050008614A1
公开(公告)日：2005-01-13
申请号：US10493884
申请日：2002-11-07
申请人： John Nieland , Christoph Rehfuess
发明人： John Nieland , Christoph Rehfuess
IPC分类号： A61K9/06 , A61K9/00 , A61K9/12 , A61K38/00 , A61K38/19 , A61K38/21 , A61K47/00 , A61K47/06 , A61K47/10 , A61K47/20 , A61K47/28 , A61K47/44 , A61P17/00 , A61P31/10 , A61P31/12 , A61P35/00
CPC分类号： A61K9/0014 , A61K38/063 , A61K38/193 , A61K38/385 , A61K47/06 , A61K47/10 , A61K47/20 , A61K47/28 , A61K2300/00
摘要： The invention relates to the use of at least one cytokine and/or chemokine in the production of a topically acting medicament for treating viral and/or mykotic skin diseases and/or tumoral diseases.
摘要翻译： 本发明涉及至少一种细胞因子和/或趋化因子在制备用于治疗病毒和/或肌肉病皮肤疾病和/或肿瘤性疾病的局部作用药物中的用途。
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