发明申请
US20050009908A1 Aqueous dispersion comprising stable nonoparticles of a water-insoluble active and an excipient like middle chain triglycerides (mct)
审中-公开
包含水不溶性活性物质和赋形剂如中链甘油三酯（mct）的稳定非颗粒的水分散体
- 专利标题： Aqueous dispersion comprising stable nonoparticles of a water-insoluble active and an excipient like middle chain triglycerides (mct)
- 专利标题（中）： 包含水不溶性活性物质和赋形剂如中链甘油三酯（mct）的稳定非颗粒的水分散体
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申请号： US10486211申请日： 2002-08-01
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公开(公告)号： US20050009908A1公开(公告)日： 2005-01-13
- 发明人: Pia Margaretha Hedberg , Tommy Skantze , Lars Von Corswant , Per Lindfors , Anna Zackrisson , Ulf Olsson
- 申请人： Pia Margaretha Hedberg , Tommy Skantze , Lars Von Corswant , Per Lindfors , Anna Zackrisson , Ulf Olsson
- 优先权： GB0119081.8 20010806; GB0212463.4 20020530
- 国际申请： PCT/GB02/03583 WO 20020801
- 主分类号： A61K9/10
- IPC分类号： A61K9/10 ; A61K9/51 ; A61K47/10 ; A61K47/14 ; A61K47/44 ; A61K9/14 ; A61K31/225
摘要：
A process for the preparation of a stable dispersion of solid particles, in an aqueous medium comprising combining (a) a first solution comprising a substantially water-insoluble substance, a water-miscible organic solvent and an inhibitor with (b) an aqueous phase comprising water and optionally a stabiliser, thereby precipitating solid particles comprising the inhibitor and the substantially water-insoluble substance; and optionally removing the water-miscible organic solvent; wherein the inhibitor is a non-polymeric hydrophobic organic compound as defined in the description. The process provides a dispersion of solid particles in an aqueous medium, which particles exhibit reduced or substantially no particle growth mediated by Ostwald ripening.
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