公开(公告)号：US20050009908A1

公开(公告)日：2005-01-13

申请号：US10486211

申请日：2002-08-01

申请人： Pia Margaretha Hedberg ,  Tommy Skantze ,  Lars Von Corswant ,  Per Lindfors ,  Anna Zackrisson ,  Ulf Olsson

发明人： Pia Margaretha Hedberg ,  Tommy Skantze ,  Lars Von Corswant ,  Per Lindfors ,  Anna Zackrisson ,  Ulf Olsson

IPC分类号： A61K9/10 ,  A61K9/51 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61K9/14 ,  A61K31/225

CPC分类号： A61K9/5138 ,  A61K9/10 ,  A61K9/5192

摘要： A process for the preparation of a stable dispersion of solid particles, in an aqueous medium comprising combining (a) a first solution comprising a substantially water-insoluble substance, a water-miscible organic solvent and an inhibitor with (b) an aqueous phase comprising water and optionally a stabiliser, thereby precipitating solid particles comprising the inhibitor and the substantially water-insoluble substance; and optionally removing the water-miscible organic solvent; wherein the inhibitor is a non-polymeric hydrophobic organic compound as defined in the description. The process provides a dispersion of solid particles in an aqueous medium, which particles exhibit reduced or substantially no particle growth mediated by Ostwald ripening.

摘要翻译： 一种在水性介质中制备固体颗粒的稳定分散体的方法，包括将（a）包含基本上不溶于水的物质，水混溶性有机溶剂和抑制剂的第一溶液与（b）含水相组合 水和任选的稳定剂，从而沉淀包含抑制剂和基本上不溶于水的物质的固体颗粒; 并任选地除去水混溶性有机溶剂; 其中所述抑制剂是如说明书中定义的非聚合疏水性有机化合物。 该方法提供固体颗粒在水性介质中的分散体，该颗粒表现出由Ostwald熟化介导的减少或基本上没有颗粒生长。