Process for the preparation of crystalline nano-particle dispersions
    2.
    发明申请
    Process for the preparation of crystalline nano-particle dispersions 失效
    制备结晶纳米颗粒分散体的方法

    公开(公告)号:US20050202092A1

    公开(公告)日:2005-09-15

    申请号:US10521617

    申请日:2003-07-14

    IPC分类号: A61K9/51 A61K9/14 G01N33/553

    摘要: A process for the preparation of a dispersion of crystalline nano-particles in an aqueous medium comprising combining (i) a first solution comprising a substantially water-insoluble substance in a water-miscible organic solvent with; (ii) an aqueous phase comprising water and optionally a stabiliser, to form a dispersion of amorphous particles; and (iii) sonicating the dispersion of amorphous particles for a sufficient period to form crystalline nano-particles of the substantially water-insoluble substance. The process provides nano-crystals with a mean hydrodynamic diameter of less than 1 micron, particularly less than 300 nm and is particularly useful for the preparation of nano-crystalline dispersions of pharmaceutical substances.

    摘要翻译: 一种在水性介质中制备结晶纳米颗粒的分散体的方法,包括将(i)在水混溶性有机溶剂中含有基本上不溶于水的物质的第一溶液与 (ii)包含水和任选的稳定剂的水相以形成无定形颗粒的分散体; 和(iii)将无定形颗粒的分散体超声处理足够的时间以形成基本上不溶于水的物质的结晶纳米颗粒。 该方法提供纳米晶体,其平均流体动力学直径小于1微米,特别是小于300nm,并且特别可用于制备药物物质的纳米结晶分散体。