Invention Application
US20050013807A1 Keratinocytes expressing exogenous angiogenic growth factors
有权
表达外源性血管生成生长因子的角质形成细胞
- Patent Title: Keratinocytes expressing exogenous angiogenic growth factors
- Patent Title (中): 表达外源性血管生成生长因子的角质形成细胞
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Application No.: US10848646Application Date: 2004-05-19
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Publication No.: US20050013807A1Publication Date: 2005-01-20
- Inventor: Allen Comer , Lynn-Allen Hoffmann
- Applicant: Allen Comer , Lynn-Allen Hoffmann
- Applicant Address: US WI Madison
- Assignee: Stratatech Corporation
- Current Assignee: Stratatech Corporation
- Current Assignee Address: US WI Madison
- Main IPC: A61K35/12
- IPC: A61K35/12 ; C07K14/515 ; C07K14/52 ; C12N5/071 ; A61K48/00 ; C12N5/08
Abstract:
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1α, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.
Public/Granted literature
- US07807148B2 Organotypically cultured skin tissue comprising NIKS cells that express exogenous HIF-1a Public/Granted day:2010-10-05
Information query
