发明申请
US20050014206A1 Method of identifying compounds that specifically inhibit the anaphase promoting complex
审中-公开
识别特异性抑制后期促进复合物的化合物的方法
- 专利标题： Method of identifying compounds that specifically inhibit the anaphase promoting complex
- 专利标题（中）： 识别特异性抑制后期促进复合物的化合物的方法
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申请号： US10825688申请日： 2004-04-16
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公开(公告)号： US20050014206A1公开(公告)日： 2005-01-20
- 发明人: Hartmut Vodermaier , Christian Gieffers , Sebastian Maurer-Stroh , Frank Eisenhaber , Jan-Michael Peters , Michael Gmachl
- 申请人： Hartmut Vodermaier , Christian Gieffers , Sebastian Maurer-Stroh , Frank Eisenhaber , Jan-Michael Peters , Michael Gmachl
- 专利权人： Boehringer Ingelhiem International GmbH
- 当前专利权人： Boehringer Ingelhiem International GmbH
- 优先权： DEEP03008908.0 20030416
- 主分类号： C12Q1/37
- IPC分类号： C12Q1/37 ; G01N33/567
摘要：
A screening method for identifying specific APC inhibitors comprises a primary screen in which a compound is tested for its ability to interfere with binding of CDH1 or CDC20 to the APC and a secondary screen, in which the compound is tested for its ability to interfere with the activation of the APC by CDH1 or CDC20.
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