专利检索 ap:"Michael Gmachl" 第 1 页

1.

发明授权
Thiazolyl-dihydro-indazole 有权
标题翻译：噻唑基 - 二氢 - 吲唑

公开(公告)号：US07691888B2

公开(公告)日：2010-04-06

申请号：US11243796

申请日：2005-10-05

申请人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel

发明人： Bodo Betzemeier , Trixi Brandl , Steffen Breitfelder , Ralph Brueckner , Thomas Gerstberger , Michael Gmachl , Matthias Grauert , Frank Hilberg , Christoph Hoenke , Matthias Hoffmann , Maria Impagnatiello , Dirk Kessler , Christian Klein , Bernd Krist , Udo Maier , Darryl McConnell , Charlotte Reither , Stefan Scheuerer , Andreas Schoop , Norbert Schweifer , Oliver Simon , Martin Steegmaier , Steffen Steurer , Irene Waizenegger , Ulrike Weyer-Czernilofsky , Andreas Zoephel

IPC分类号： A61K31/429 , A61K31/4162 , C07D513/02 , C07D417/14

CPC分类号： C07D513/04 , C07D277/84

摘要： The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.

摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病，以及其用于制备具有上述属性。

2.

发明申请
Method of identifying compounds that specifically inhibit the anaphase promoting complex 审中-公开
标题翻译：识别特异性抑制后期促进复合物的化合物的方法

公开(公告)号：US20050014206A1

公开(公告)日：2005-01-20

申请号：US10825688

申请日：2004-04-16

申请人： Hartmut Vodermaier , Christian Gieffers , Sebastian Maurer-Stroh , Frank Eisenhaber , Jan-Michael Peters , Michael Gmachl

发明人： Hartmut Vodermaier , Christian Gieffers , Sebastian Maurer-Stroh , Frank Eisenhaber , Jan-Michael Peters , Michael Gmachl

IPC分类号： C12Q1/37 , G01N33/567

CPC分类号： C12Q1/37 , G01N2500/02

摘要： A screening method for identifying specific APC inhibitors comprises a primary screen in which a compound is tested for its ability to interfere with binding of CDH1 or CDC20 to the APC and a secondary screen, in which the compound is tested for its ability to interfere with the activation of the APC by CDH1 or CDC20.

摘要翻译： 用于鉴定特异性APC抑制剂的筛选方法包括主筛选，其中化合物被测试其干扰CDH1或CDC20与APC结合的能力和次级筛，其中化合物被测试其干扰通过CDH1或CDC20激活APC。