发明申请
US20050020650A1 3-amido-1,2-benzoisoxazole derivatives, process for preparation, and use thereof
失效
3-酰氨基-1,2-苯并异恶唑衍生物，其制备方法和用途
- 专利标题： 3-amido-1,2-benzoisoxazole derivatives, process for preparation, and use thereof
- 专利标题（中）： 3-酰氨基-1,2-苯并异恶唑衍生物，其制备方法和用途
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申请号： US10493702申请日： 2002-11-05
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公开(公告)号： US20050020650A1公开(公告)日： 2005-01-27
- 发明人: Jin-Soo Lee , Seok-Hoon Ahn , Young-Goo Jin , Sang-Mi Jin , Sae-Kwang Ku , Jei-Man Rye , Yong-Ho Chung , Eun-Joo Kim , Sun-Ki Cho
- 申请人： Jin-Soo Lee , Seok-Hoon Ahn , Young-Goo Jin , Sang-Mi Jin , Sae-Kwang Ku , Jei-Man Rye , Yong-Ho Chung , Eun-Joo Kim , Sun-Ki Cho
- 优先权： KR2001/69013 20011106
- 国际申请： PCT/KR02/02058 WO 20021105
- 主分类号： A61K31/423
- IPC分类号： A61K31/423 ; A61P19/10 ; C07D261/20 ; A61K31/42
摘要：
The present invention relates to 3-amido-1,2-benzoisoxazole derivatives and their salts represented by formula 1, processes for preparation and usees thereof. More particularly, it relates to a method for improving its bioavailability introducing amino acid residue to the amine group of a 3-amido-1,2-benzoisoxazole. The compounds according to the present invention are used as an antagonist against Leukotriene-B-4 receptor, an inhibitor or therapeutics of osteoroposis, thus inhibiting osteolysis and stimulating osteogensis.
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