公开(公告)号：US20050020650A1

公开(公告)日：2005-01-27

申请号：US10493702

申请日：2002-11-05

Applicant: Jin-Soo Lee ,  Seok-Hoon Ahn ,  Young-Goo Jin ,  Sang-Mi Jin ,  Sae-Kwang Ku ,  Jei-Man Rye ,  Yong-Ho Chung ,  Eun-Joo Kim ,  Sun-Ki Cho

Inventor： Jin-Soo Lee ,  Seok-Hoon Ahn ,  Young-Goo Jin ,  Sang-Mi Jin ,  Sae-Kwang Ku ,  Jei-Man Rye ,  Yong-Ho Chung ,  Eun-Joo Kim ,  Sun-Ki Cho

IPC: A61K31/423 ,  A61P19/10 ,  C07D261/20 ,  A61K31/42

CPC classification number: C07D261/20

Abstract: The present invention relates to 3-amido-1,2-benzoisoxazole derivatives and their salts represented by formula 1, processes for preparation and usees thereof. More particularly, it relates to a method for improving its bioavailability introducing amino acid residue to the amine group of a 3-amido-1,2-benzoisoxazole. The compounds according to the present invention are used as an antagonist against Leukotriene-B-4 receptor, an inhibitor or therapeutics of osteoroposis, thus inhibiting osteolysis and stimulating osteogensis.

Abstract translation: 本发明涉及由式1表示的3-酰氨基-1,2-苯并异恶唑衍生物及其盐，其制备方法及用途。 更具体地说，涉及将氨基酸残基引入3-氨基-1,2-苯并异恶唑的胺基的生物利用度提高的方法。 根据本发明的化合物用作抗白细胞三烯-B-4受体的拮抗剂，抑制剂或骨质疏松症的治疗剂，从而抑制骨质溶解和刺激骨质疏松。

公开(公告)号：US06650245B2

公开(公告)日：2003-11-18

申请号：US10046260

申请日：2002-01-16

Applicant: Yong Ho Chung

Inventor： Yong Ho Chung

IPC: G08B2100

CPC classification number: H01H9/542 ,  H01H2009/543 ,  H02H7/08 ,  H02H9/001 ,  H02P25/04

Abstract: A multi-functional hybrid contactor has a motor protection function against an abnormal state in addition to the starting, running and stopping of the motor, the same effect as the case that an electronic motor protection relay (EMPR) is connected in parallel can be obtained with only one multi-functional hybrid contactor. Also, the size of the product is much reduced compared to the case that the electric motor protection relay (EMPR) is connected in parallel, and its cost can be reduced. In addition, since the semiconductor switch is turned on only in the initial stage of starting and stopping, the rated current capacity and size of the semiconductor switch can be considerably reduced compared to the conventional soft starting method in which the semiconductor switch is used for controlling of all of starting, running and stopping.

公开(公告)号：US06552196B2

公开(公告)日：2003-04-22

申请号：US09946541

申请日：2001-09-06

Applicant: Sung-Joon Yoon ,  Yong-Ho Chung ,  Chi-Woo Lee ,  Yoon-Seok Oh ,  Nam-Doo Kim ,  Jae-Kyung Lim ,  Yoon-Ho Jin

Inventor： Sung-Joon Yoon ,  Yong-Ho Chung ,  Chi-Woo Lee ,  Yoon-Seok Oh ,  Nam-Doo Kim ,  Jae-Kyung Lim ,  Yoon-Ho Jin

IPC: C07D22104

CPC classification number: C07D487/10

Abstract: The present invention relates to quinolonecarboxylic acid derivatives having more excellent and broad antibacterial activities than the existing quinolone-series antibiotic. More specifically, it pertains to novel quinolonecarboxylic acid derivative represented by following formula 1, which have a derivative of 7-[8-(alkoxyimino)-2,6-diazaspiro[3.4]oct-6-yl] as a substituent, and pharmaceutically acceptable salts and isomers thereof: Wherein A is C—H, C—F, C—Cl, C—O—CH3 or N; Y is H or amino; R1 is cyclopropyl or 2,4-difluorsophenyl R2 is C1-4 alkyl; and R3 is H or C1-4 alkyl.

Abstract translation: 本发明涉及具有比现有的喹诺酮系列抗生素更优异和更广泛的抗菌活性的喹诺酮羧酸衍生物。 更具体地说，涉及具有7- [8-（烷氧基亚氨基）-2,6-二氮杂螺[3.4]辛-6-基]作为取代基的衍生物的下式1所示的新型喹诺酮羧酸衍生物， 其可接受的盐和异构体：其中A是CH，CF，C-Cl，CO-CH 3或N; Y是H或氨基; R1是环丙基或2,4-二氟苯基R2是C1-4烷基; 且R 3为H或C 1-4烷基。

公开(公告)号：US08227496B2

公开(公告)日：2012-07-24

申请号：US12689878

申请日：2010-01-19

Applicant: Hong-Suk Suh ,  Jin Soo Lee ,  Pan-Soo Kim ,  Yun-Ha Hwang ,  Jei Man Ryu ,  Yong-Ho Chung ,  Eun-Joo Kim ,  Do-Hui Kim ,  Yong-Youp Park

Inventor： Hong-Suk Suh ,  Jin Soo Lee ,  Pan-Soo Kim ,  Yun-Ha Hwang ,  Jei Man Ryu ,  Yong-Ho Chung ,  Eun-Joo Kim ,  Do-Hui Kim ,  Yong-Youp Park

IPC: A01N43/78 ,  A01N37/52 ,  A61K31/425 ,  A61K31/155 ,  C07D277/60 ,  C07D416/00 ,  C07C249/00 ,  C07C251/00 ,  C07C259/00 ,  C07C291/00

CPC classification number: A61K31/426 ,  Y10S514/878

Abstract: A method of treating osteoporosis comprising administering to a subject a composition comprising a compound, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine or a salt thereof, is described. A method of inhibiting osteoclast activity and stimulating osteoblast activity in a subject also is described.

Abstract translation: 一种治疗骨质疏松症的方法，包括向受试者施用包含化合物4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基} - 苄脒或 其盐。 还描述了抑制破骨细胞活性并刺激受试者成骨细胞活性的方法。

公开(公告)号：US07291638B2

公开(公告)日：2007-11-06

申请号：US10493702

申请日：2002-11-05

Applicant: Jin-Soo Lee ,  Seok-Hoon Ahn ,  Young-Goo Jin ,  Sang-Mi Jin ,  Sae-Kwang Ku ,  Jei-Man Rye ,  Yong-Ho Chung ,  Eun-Joo Kim ,  Sun-Ki Cho

Inventor： Jin-Soo Lee ,  Seok-Hoon Ahn ,  Young-Goo Jin ,  Sang-Mi Jin ,  Sae-Kwang Ku ,  Jei-Man Rye ,  Yong-Ho Chung ,  Eun-Joo Kim ,  Sun-Ki Cho

IPC: A61K31/42 ,  C07D261/20

CPC classification number: C07D261/20

Abstract: The present invention relates to 3-amido-1,2-benzoisoxazole derivatives and their salts represented by formula 1, processes for preparation and usees thereof. More particularly, it relates to a method for improving its bioavailability introducing amino acid residue to the amine group of a 3-amido-1,2-benzoisoxazole. The compounds according to the present invention are used as an antagonist against Leukotriene-B-4 receptor, an inhibitor or therapeutics of osteoroposis, thus inhibiting osteolysis and stimulating osteogensis.

Abstract translation: 本发明涉及由式1表示的3-酰氨基-1,2-苯并异恶唑衍生物及其盐，其制备方法及用途。 更具体地说，本发明涉及将氨基酸残基引入3-氨基-1,2-苯并异恶唑的胺基的方法。 根据本发明的化合物用作抗白细胞三烯-B-4受体的拮抗剂，抑制剂或骨质疏松症的治疗剂，从而抑制骨质溶解和刺激骨质疏松。

公开(公告)号：US06858727B2

公开(公告)日：2005-02-22

申请号：US10344267

申请日：2001-08-06

Applicant: Cheol-hae Lee ,  Bong-jin Kim ,  Do-kyu Pyun ,  Won-jang Jeong ,  Jae-hak Kim ,  Hee-jung Chung ,  Hyun-jung Kwak ,  Eun-jung Kim ,  Shin-seup Song ,  Yong-ho Chung

Inventor： Cheol-hae Lee ,  Bong-jin Kim ,  Do-kyu Pyun ,  Won-jang Jeong ,  Jae-hak Kim ,  Hee-jung Chung ,  Hyun-jung Kwak ,  Eun-jung Kim ,  Shin-seup Song ,  Yong-ho Chung

IPC: C07D413/14 ,  C07D205/08 ,  C07D265/06 ,  C07D265/14 ,  C07D413/06 ,  C07D487/04 ,  C07D498/10 ,  C07F7/18 ,  C07F9/572 ,  C07F9/6561 ,  C07F9/568

CPC classification number: C07D413/06 ,  C07D205/08 ,  C07D265/06 ,  C07D265/14 ,  C07D487/04 ,  C07F9/65611 ,  Y02P20/55

Abstract: There is disclosed an azetidinone compound of the formula (I): wherein R is hydrogen, or a hydroxy protecting group, R1 and R2 are each independently alkyl of 1-15 carbon atoms, benzyl or cyclized together with the carbon atom to which they are attached to form a 5 or 6-membered cyclic hydrocarbon or a heterocyclic radical having one or two hetero ring atoms, said hetero ring atoms being selected from the group consisting of O and S; R3 is lower alkyl or —COO(lower alkyl) R4 is phenyl, or phenyl substituted with halogen, lower alkoxy or nitro which is useful as a synthetic intermediate to the 1′β-methylcarbapenem-type antibacterial agent.

Abstract translation: 公开了式（I）的氮杂环丁酮化合物：其中R是氢或羟基保护基，R 1和R 2各自独立地是1-15个碳原子的烷基，或与它们所在的碳原子一起环化 连接以形成具有一个或两个杂环原子的5或6元环烃或杂环基团，所述杂环原子选自O和S; R3是低级烷基或-COO（低级烷基）R4是苯基，或被卤素，低级烷氧基或硝基取代的苯基，其可用作1'-二甲基碳青霉烯型抗菌剂的合成中间体。

公开(公告)号：US06436921B1

公开(公告)日：2002-08-20

申请号：US09508656

申请日：2000-05-18

Applicant: Sang Woo Park ,  Dong Kin Kim ,  Kye-Jung Shin ,  Yong Koo Kang ,  Yong Zu Kim ,  Yong Ho Chung ,  Hong Woo Lee ,  Jae Doo Huh ,  Sang Joo Lee ,  Il Hong Suh ,  Bong Suk Ko

Inventor： Sang Woo Park ,  Dong Kin Kim ,  Kye-Jung Shin ,  Yong Koo Kang ,  Yong Zu Kim ,  Yong Ho Chung ,  Hong Woo Lee ,  Jae Doo Huh ,  Sang Joo Lee ,  Il Hong Suh ,  Bong Suk Ko

IPC: C07D47720

CPC classification number: C07D477/20 ,  C07D207/16 ,  Y02P20/55

Abstract: The present invention relates to carbapenem derivatives of Formula I, wherein X is carbonyl or sulfonyl, and a preparation method thereof. The carbapenem derivatives of the invention have excellent antibacterial properties and are thus useful as antibiotics.

Abstract translation: 本发明涉及式I的碳青霉烯衍生物及其制备方法，其中X为羰基或磺酰基。 本发明的碳青霉烯衍生物具有优异的抗菌性能，因此可用作抗生素。

公开(公告)号：US5929103A

公开(公告)日：1999-07-27

申请号：US915726

申请日：1997-08-21

Applicant: Sung June Yoon ,  Yong Ho Chung ,  Moon Sun Lee ,  Dong Rack Choi ,  Jung A Lee ,  Hee Soon Lee ,  Hae Ran Yun ,  Dug Keun Lee ,  Eun Yi Moon ,  Hyun Sook Hwang ,  Chung Ha Choi ,  Sang Hun Jung

Inventor： Sung June Yoon ,  Yong Ho Chung ,  Moon Sun Lee ,  Dong Rack Choi ,  Jung A Lee ,  Hee Soon Lee ,  Hae Ran Yun ,  Dug Keun Lee ,  Eun Yi Moon ,  Hyun Sook Hwang ,  Chung Ha Choi ,  Sang Hun Jung

IPC: A61K31/4178 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61P35/00 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  A61K31/415

CPC classification number: C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14

Abstract: The present invention relates to a novel arylsulfonylimidazolone derivative represented by the following formula (I) which shows a superior antineoplastic activity in contrast to the known sulfonylurea antitumor agents as well as little side effect: ##STR1## and its pharmaceutically acceptable salt and stereoisomer, in which ----, R.sub.1, and R.sub.2 are as defined in the specification.

Abstract translation: 本发明涉及与已知的磺酰脲类抗肿瘤剂相比具有优异的抗肿瘤活性以及其药学上可接受的盐和立体异构体的下式（I）所示的新型芳基磺酰基咪唑啉酮衍生物，其中+ E ，非+ EE，R1和R2如说明书中所定义。

公开(公告)号：US06753430B2

公开(公告)日：2004-06-22

申请号：US10600631

申请日：2003-06-20

Applicant: Sung June Yoon ,  Yong Ho Chung ,  Chi Woo Lee ,  Jin Soo Lee ,  Nam Doo Kim ,  Yoon Ho Jin ,  Wan Jin Song ,  Ik Hoe Kim ,  Wang Yong Yang ,  Dong Rack Choi ,  Jung Han Shin

Inventor： Sung June Yoon ,  Yong Ho Chung ,  Chi Woo Lee ,  Jin Soo Lee ,  Nam Doo Kim ,  Yoon Ho Jin ,  Wan Jin Song ,  Ik Hoe Kim ,  Wang Yong Yang ,  Dong Rack Choi ,  Jung Han Shin

IPC: C07D47102

CPC classification number: C07D401/04 ,  C07D471/04 ,  C07D487/10

Abstract: The present invention relates to optically active quinoline carboxylic acid derivatives, their pharmaceutically acceptable salts, their solvates, and a process for the preparation thereof. More specifically, the present invention relates to optically active quinoline carboxylic acid derivatives containing 4-aminomethyl-4methyl-3-(Z)-alkoxyiminopyrrolidine substituents causing optical activity at the 7-position of the quinolone nuclei. As the compounds of the present invention have superior antibacterial activity and pharmacokinetic profiles to their enantiomers, their racemates and conventional antibacterial agents, with nearly no phototoxicity, the compounds of this invention are useful for antibacterial agents.

Abstract translation: 本发明涉及光学活性喹啉羧酸衍生物，其药学上可接受的盐，其溶剂合物及其制备方法。 更具体地说，本发明涉及含有在喹诺酮核的7-位引起光学活性的4-氨基甲基-4-甲基-3-（Z） - 烷氧基亚氨基吡咯烷基取代基的光学活性喹啉羧酸衍生物。 由于本发明的化合物对其对映异构体，它们的外消旋体和常规的抗菌剂具有优异的抗细菌活性和药代动力学特性，几乎没有光毒性，本发明的化合物可用于抗菌剂。

公开(公告)号：US06649763B1

公开(公告)日：2003-11-18

申请号：US09979644

申请日：2001-11-16

Applicant: Sung June Yoon ,  Yong Ho Chung ,  Chi Woo Lee ,  Jin Soo Lee ,  Nam Doo Kim ,  Yoon Ho Jin ,  Wan Jin Song ,  Ik Hoe Kim ,  Wang Yong Yang ,  Dong Rack Choi ,  Jung Han Shin

Inventor： Sung June Yoon ,  Yong Ho Chung ,  Chi Woo Lee ,  Jin Soo Lee ,  Nam Doo Kim ,  Yoon Ho Jin ,  Wan Jin Song ,  Ik Hoe Kim ,  Wang Yong Yang ,  Dong Rack Choi ,  Jung Han Shin

IPC: C07D215233

CPC classification number: C07D401/04 ,  C07D471/04 ,  C07D487/10

Abstract: The present invention relates to optically active quinoline carboxylic acid derivatives, their pharmaceutically acceptable salts, their solvates, and a process for the preparation thereof. More specifically, the present invention relates to optically active quinoline carboxylic acid derivatives containing 4-aminomethyl-4-methyl-3-(Z)-alkoxyirninopyrrolidine substituents causing optical activity at the 7-position of the quinolone nuclei. As the compounds of the present invention have superior antibacterial activity and pharmacokinetic profiles to their enantiomers, their racemates and conventional antibacterial agents, with nearly no phototoxicity, the compounds of this invention are useful for antibacterial agents.

Abstract translation: 本发明涉及光学活性喹啉羧酸衍生物，其药学上可接受的盐，其溶剂合物及其制备方法。 更具体地说，本发明涉及含有4-氨基甲基-4-甲基-3-（Z） - 烷氧基亚氨基吡咯烷基取代基的喹啉羧酸衍生物，其在喹诺酮核的7-位引起光学活性。 由于本发明的化合物对其对映异构体，它们的外消旋体和常规抗菌剂具有优异的抗菌活性和药代动力学特性，几乎没有光毒性，所以本发明的化合物可用于抗菌剂。