发明申请
- 专利标题: Hydroxyfattysulfonic acid analogs
- 专利标题(中): 羟基脂肪磺酸类似物
-
申请号: US10489204申请日: 2002-09-09
-
公开(公告)号: US20050020680A1公开(公告)日: 2005-01-27
- 发明人: John Falck , Noriyuki Miyata , Naoya Ono , Tomomichi Chonan , Hitomi Hirano , Yoshihisa Toda , Tohru Tanami , Shigeru Okuyama
- 申请人: John Falck , Noriyuki Miyata , Naoya Ono , Tomomichi Chonan , Hitomi Hirano , Yoshihisa Toda , Tohru Tanami , Shigeru Okuyama
- 国际申请: PCT/US02/25970 WO 20020909
- 主分类号: C07C33/044
- IPC分类号: C07C33/044 ; C07C33/42 ; C07C59/42 ; C07C59/46 ; C07C59/60 ; C07C69/708 ; C07C235/28 ; C07C255/15 ; C07C259/06 ; C07C309/10 ; C07C309/20 ; C07C309/23 ; C07C309/24 ; C07C309/68 ; C07C311/17 ; C07C311/51 ; C07C317/44 ; C07C323/52 ; C07C323/66 ; C07D257/04 ; C07D277/34 ; A61K31/185 ; C07
摘要:
A hydroxyfattysulfonic acid analog represented by Formula (I): wherein X is an ethylene group, a vinylene group or an ethynylene group; Y is an ethylene group, a vinylene group, an ethynylene group, OCH2 or S(O)pCH2 wherein p is 0, 1 or 2; m is an integer of 1 to 5 inclusive; n is an integer of 0 to 4 inclusive; R1 is a C1-8 alkyl group, a C3-8 cycloalkyl group, a C1-4 alkyl group substituted with a C3-8 cycloalkyl group, a C1-4 alkyl group substituted with an aryl group or a C1-4 alkyl group substituted with an aryloxy group; R2 is a hydrogen atom or a methyl group; R1 and R2 together with the carbon atom to which they are attached may form a C3-8 cycloalkyl group; R3 is a hydrogen atom or a C2-8 acyl group; R4 is OR5 or NHR6, wherein R5 is a hydrogen atom, a C1-4 alkyl group, an alkali metal, an alkaline earth metal or an ammonium group and R6 is a hydrogen atom or a C1-4 alkyl group; or a pharmaceutically acceptable salt or a hydrate thereof. The compounds of the present invention are useful as an elastase release inhibitor.
信息查询