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37 条记录 (耗时 0.034 秒)

    Triazole derivative
    1.
    发明授权
    Triazole derivative 失效
    三唑衍生物

    公开(公告)号：US08022091B2

    公开(公告)日：2011-09-20

    申请号：US12278054

    申请日：2007-02-05

    申请人： Naoya Ono ,  Tetsuo Takayama ,  Fumiyasu Shiozawa ,  Hironori Katakai ,  Tetsuya Yabuuchi ,  Tomomi Ota ,  Makoto Yagi ,  Masakazu Sato

    发明人： Naoya Ono ,  Tetsuo Takayama ,  Fumiyasu Shiozawa ,  Hironori Katakai ,  Tetsuya Yabuuchi ,  Tomomi Ota ,  Makoto Yagi ,  Masakazu Sato

    IPC分类号： A01N43/64 ,  A61K31/41 ,  C07D249/12

    CPC分类号： C07D249/08

    摘要： An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P1), and is useful as a pharmaceutical compound. A compound or a pharmaceutically acceptable salt thereof, which compound is represented by the formula below (where A represents an oxygen atom, a sulfur atom, a group represented by Formula —SO—, a group represented by Formula —SO2—, or the like, R1 represents a hydrogen atom, an alkyl group having 1-6 carbon atoms, or the like, R1A represents a hydrogen atom or the like, R2 represents an alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-6 carbon atoms, or the like, R3 represents an aryl group, R4 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms and optionally substituted with a carboxyl group, and R5 represents an alkyl group having 1-10 carbon atoms, a cycloalkyl group having 3-8 carbon atoms, an aryl group which is optionally substituted, or the like).

    摘要翻译： 本发明的目的是提供具有抑制S1P与其受体Edg-1（S1P1）结合的作用的化合物，可用作药物化合物。 化合物或其药学上可接受的盐，其化合物由下式表示（其中A表示氧原子，硫原子，由式-SO-表示的基团，由式-SO2-表示的基团等） R1表示氢原子，具有1-6个碳原子的烷基等，R1A表示氢原子等，R2表示具有1-6个碳原子的烷基，具有3-6个碳原子的环烷基 原子等，R 3表示芳基，R 4表示氢原子或具有1-6个碳原子并且任选被羧基取代的烷基，R 5表示具有1-10个碳原子的烷基，环烷基 具有3-8个碳原子的基团，任选取代的芳基等）。

    Prostaglandin derivatives
    3.
    发明申请
    Prostaglandin derivatives 审中-公开
    前列腺素衍生物

    公开(公告)号：US20060270740A1

    公开(公告)日：2006-11-30

    申请号：US10545785

    申请日：2004-02-19

    申请人： Fumie Sato ,  Tohru Tanami ,  Naoya Ono ,  Makoto Yagi ,  Takayuki Seki ,  Mariko Sato

    发明人： Fumie Sato ,  Tohru Tanami ,  Naoya Ono ,  Makoto Yagi ,  Takayuki Seki ,  Mariko Sato

    IPC分类号： A61K31/557

    CPC分类号： C07C405/0016

    摘要： A prostaglandin derivative represented by the formula (wherein X is a halogen atom; Y is ethylene group, vinylene group or ethylylene group; Z is a group represented by —(CH2)m, —O(CH2)n— or —S(O)p—(CH2)n— (m is an integer of 0 to 3; n is an integer of 0 to 2; and p is an integer of 0 to 2); R1 is a hydrogen atom, a C1-5 alkyl group or a substituted C1-5 alkyl group; R2 is a C3-10 cycloalkyl group, a C3-10 cycloalkyl group substituted by C1-4 alkyl group or C4-15 cycloalkylalkyl group; and R3 is a hydrogen atom, a halogen atom or a C1-5 alkyl group or a substituted C1-5 alkyl group), a pharmaceutically acceptable salt thereof or a hydrate thereof which has an excellent antagonism to prostaglandin DP receptor and, therefore, is useful against diseases such as allergic rhinitis, nasal obstruction, asthma, allergic conjunctivitis, systemic mastocytosis and disorder of systemic mast cell activation.

    摘要翻译： 由式（其中X是卤素原子; Y是亚乙基，亚乙烯基或亚乙基）表示的前列腺素衍生物; Z是由 - （CH 2 CH 2）m表示的基团， （CH 2）n - 或 - （CH 2）n - （CH 2）n - ）n（m为0〜3的整数，n为0〜2的整数，p为0〜2的整数），R 1〜 氢原子，C 1-5烷基或取代的C 1-5烷基; R 2是C 1 -C 6烷基， 3-10个环烷基，被C 1-4烷基取代的C 3-10环烷基或C 1-4 - >环烷基烷基; R 3是氢原子，卤素原子或C 1-5烷基或取代的C 1-5 - >烷基），其药学上可接受的盐或其水合物，其对前列腺素DP受体具有优异的拮抗作用，因此可用于治疗过敏性鼻炎，鼻塞 离子，哮喘，过敏性结膜炎，全身肥大细胞增多症和系统性肥大细胞活化紊乱。

    Prostaglandin E1 derivatives
    6.
    发明授权
    Prostaglandin E1 derivatives 失效
    前列腺素E1衍生物

    公开(公告)号：US06455584B1

    公开(公告)日：2002-09-24

    申请号：US09937782

    申请日：2002-01-04

    申请人： Fumie Sato ,  Tohru Tanami ,  Hideo Tanaka ,  Naoya Ono ,  Makoto Yagi ,  Hitomi Hirano

    发明人： Fumie Sato ,  Tohru Tanami ,  Hideo Tanaka ,  Naoya Ono ,  Makoto Yagi ,  Hitomi Hirano

    IPC分类号： C07C17700

    CPC分类号： C07C405/00 ,  A61K31/5575 ,  C07C405/0033

    摘要： To provide a prostaglandin derivative represented by the formula: wherein A is an ethylene group, a vinylene group, an ethynylene group, O(CH2)q or S(O)r(CH2)q, R1 is a C3-10 cycloalkyl group, a C1-4 alkyl-C3-10 cycloalkyl group, a C3-10 cycloalkyl-C1-4 alkyl group, a C1-10 alkyl group, a C1-10 alkyl group substituted with hydroxyl group(s) or C1-4 alkoxy group(s), a C2-10 alkenyl group, a C2-10 alkenyl group substituted with hydroxyl group(s) or C1-4 alkoxy group(s), a C2-10 alkynyl group, a C2-10 alkynyl group substituted with hydroxyl group(s) or C1-4 alkoxy group(s) or a bridged cyclic hydrocarbon group, R2 is a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl group, m is an integer of 1 to 5, n is an integer of 1 to 4, p is 0, 1 or 2, q is an integer of 1 to 5 and r is 0, 1 or 2; a pharmaceutically acceptable salt thereof or a hydrate thereof exhibit excellent action in inhibiting the growth of vascular smooth muscle and is useful as a drug for inhibition of restenosis after percutaneous transluminal coronary angioplasty.

    摘要翻译： 提供由下式表示的前列腺素衍生物：其中A是亚乙基，亚乙烯基，亚乙炔基，O（CH 2）q或S（O）r（CH 2）q，R 1是C 3-10环烷基， C 1-4烷基-C 3-10环烷基，C 3-10环烷基-C 1-4烷基，C 1-10烷基，被羟基或C 1-4烷氧基取代的C 1-10烷基 C2-10链烯基，被羟基或C1-4烷氧基取代的C2-10烯基，C2-10炔基，被羟基取代的C2-10炔基 基团或C 1-4烷氧基或桥连环烃基，R 2是氢原子，C 1-10烷基或C 3-10环烷基，m是1至5的整数，n 是1〜4的整数，p为0,1或2，q为1〜5的整数，r为0,1或2。 其药学上可接受的盐或其水合物在抑制血管平滑肌的生长中表现出优异的作用，并且可用作用于抑制经皮腔内冠状动脉成形术后再狭窄的药物。

    Prostaglandin derivatives
    7.
    发明授权
    Prostaglandin derivatives 失效
    前列腺素衍生物

    公开(公告)号：US5545666A

    公开(公告)日：1996-08-13

    申请号：US290745

    申请日：1995-04-19

    申请人： Fumie Sato ,  Takehiro Amano ,  Kazuya Kameo ,  Tohru Tanami ,  Masaru Mutoh ,  Naoya Ono ,  Jun Goto

    发明人： Fumie Sato ,  Takehiro Amano ,  Kazuya Kameo ,  Tohru Tanami ,  Masaru Mutoh ,  Naoya Ono ,  Jun Goto

    IPC分类号： C07C405/00 ,  C01C405/00 ,  A61K31/557

    CPC分类号： C07C405/0016

    摘要： A prostaglandin derivative represented by formula ##STR1## wherein R.sup.1 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group, and R.sup.2 represents a cyclohexyl group or a cyclopentylmethyl group. This compound has physiological activities such as platelet aggregation-inhibiting action, renal blood vessel and coronary blood vessel-dilating actions and the like, and is useful for treatment of renal failure and diseases of circulatory organs.

    摘要翻译： PCT No.PCT / JP93 / 01493 Sec。 371日期1995年04月19日 102（e）1995年4月19日PCT PCT 1993年10月18日PCT公布。 公开号WO94 / 08959 日本1994年4月28日由式表示的前列腺素衍生物，其中R1表示氢原子或C1-C6烷基，R2表示环己基或环戊基甲基。 该化合物具有血小板聚集抑制作用，肾血管和冠状血管扩张作用等的生理活性，可用于治疗肾衰竭和循环器官疾病。

    Method and apparatus for clinical analysis
    8.
    发明授权
    Method and apparatus for clinical analysis 失效
    临床分析方法和装置

    公开(公告)号：US4708940A

    公开(公告)日：1987-11-24

    申请号：US473867

    申请日：1983-03-10

    申请人： Kasumi Yoshida ,  Nobuyoshi Takano ,  Naoya Ono

    发明人： Kasumi Yoshida ,  Nobuyoshi Takano ,  Naoya Ono

    IPC分类号： G01N33/48 ,  B04B5/04 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  G01N21/07 ,  G01N21/11 ,  G01N37/00

    CPC分类号： G01N35/0095 ,  B04B5/0421 ,  B04B2011/046 ,  G01N2035/00495 ,  G01N2035/00504 ,  G01N2035/1025 ,  G01N2035/1086 ,  Y10T436/111666

    摘要： A clinical analyzer with an analyzing section having a reaction tube and photometer, and a sampling section having a sample transfer pipe and centrifugal separator which also serves as a sampler. Sample containers containing blood are set on a plurality of container holders through an aperture formed in the cover of the centrifugal separator. A rotor with the container holders mounted thereon is rotated at a low speed intermittently so that each of the container holders is positioned at the container setting position in a predetermined order in which a container holder which is not located adjacently to the previously positioned container holder is positioned next.Subsequently, the rotor is rotated at a high speed for a predetermined period so that the sample liquid in each sample container centrifugally separated. After the centrifugal separation, the rotor is rotated at a low speed intermittently so that the sample containers set on the container holders are positioned to the sample take-out position in the same order as in setting the sample containers. A pipe is inserted through a sample transfer hole formed in the cover of the centrifugal separator into the sample container, and the sample liquid is pumped up and transported to the analyzing section. This series of operations is repeated and a plurality of samples are measured for items of analysis by the photometer sequentially.

    摘要翻译： 一种具有分析部分的临床分析器，其具有反应管和光度计，以及具有用作取样器的样品传送管和离心分离器的取样部分。 含有血液的样品容器通过形成在离心分离器的盖的孔中而设置在多个容器保持器上。 安装有容器保持器的转子以低速间歇地旋转，使得每个容器保持器以预定顺序定位在容器设置位置，在该预定顺序中，不位于与先前定位的容器保持器相邻的容器保持器 下一个定位。 随后，将转子高速旋转一定时间，使每个样品容器中的样品液体离心分离。 在离心分离之后，转子以低速间歇地旋转，使得设置在容器保持器上的样品容器以与设置样品容器相同的顺序位于样品取出位置。 将管道通过形成在离心分离器的盖的样品传送孔插入到样品容器中，并将样品液体泵送并输送到分析部。 重复该系列操作，并依次通过光度计测量多个样品的分析项目。

    AMIDINE COMPOUND OR SALT THEREOF
    9.
    发明申请
    AMIDINE COMPOUND OR SALT THEREOF 有权
    氨基化合物或其盐

    公开(公告)号：US20140155597A1

    公开(公告)日：2014-06-05

    申请号：US14235686

    申请日：2012-07-27

    申请人： Tetsuya Tanikawa ,  Yasunobu Ushiki ,  Fumihito Ushiyama ,  Toru Yamaguchi ,  Naoya Ono ,  Keiko Yamamoto ,  Risa Tsuruta ,  Yasuhiro Tsutsui ,  Noritomo Fujino ,  Ayumu Mori

    发明人： Tetsuya Tanikawa ,  Yasunobu Ushiki ,  Fumihito Ushiyama ,  Toru Yamaguchi ,  Naoya Ono ,  Keiko Yamamoto ,  Risa Tsuruta ,  Yasuhiro Tsutsui ,  Noritomo Fujino ,  Ayumu Mori

    IPC分类号： C07D417/12 ,  C07D285/08 ,  C07D277/56 ,  C07D417/04 ,  C07D277/28

    CPC分类号： C07D417/12 ,  C07D277/20 ,  C07D277/28 ,  C07D277/30 ,  C07D277/34 ,  C07D277/48 ,  C07D277/56 ,  C07D285/08 ,  C07D417/04

    摘要： The purpose of the present invention is to provide a novel compound which has an anti-fungal activity on pathogenic fungi including fungi belonging to the genus Candida, the genus Aspergillus and the genus Trichophyton and is useful as a medicinal agent. A compound represented by formula (I) (wherein A1 represents a nitrogen atom or a group represented by formula CR6; A2 and A3 are the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; R1 represents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; R2 and R3 are the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 haloalkyl group or a C1-6 alkoxy group; and R4 and R5 are the same as or different from each other and independently represent a hydrogen atom, a C1-6 haloalkyl group, a C1-6 alkyl group or the like) or a salt thereof is useful as an anti-fungal agent.

    摘要翻译： 本发明的目的是提供一种对致病真菌具有抗真菌活性的新型化合物，其包括属于假丝酵母属，曲霉属和毛癣菌属的真菌，并且可用作药剂。 由式（I）表示的化合物（其中，A1表示氮原子或式CR6表示的基团; A2和A3彼此相同或不同，独立地表示氮原子或式CH表示的基团; R1 表示可以被1〜5个独立地选自取代基（2）等的取代基取代的芳基; R2和R3彼此相同或不同，独立地表示氢原子，卤素原子， C 1-6烷基，C 1-6卤代烷基或C 1-6烷氧基; R 4和R 5相同或不同，独立地表示氢原子，C1-6卤代烷基，C1- 6烷基等）或其盐可用作抗真菌剂。