- 专利标题： Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders
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申请号： US10855211申请日： 2004-05-26
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公开(公告)号： US20050026832A1公开(公告)日： 2005-02-03
- 发明人: Sean Adams , Audrey Goddard , Austin Gurney , Linu John , Timothy Stewart , Elizabeth Tomlinson , Xing Yu
- 申请人： Sean Adams , Audrey Goddard , Austin Gurney , Linu John , Timothy Stewart , Elizabeth Tomlinson , Xing Yu
- 专利权人： GENENTECH, INC.
- 当前专利权人： GENENTECH, INC.
- 优先权： WOPCT/US99/20594 19990908; WOPCT/US99/21090 19990915; WOPCT/US99/30999 19991220; WOPCT/US00/04414 20000222
- 主分类号： A61K38/18
- IPC分类号： A61K38/18 ; A61K48/00 ; C12N15/85
摘要：
The present invention is directed to novel polypeptides belonging to the fibroblast growth factor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Furthermore, methods of treating obesity are provided.
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