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公开(公告)号：US09650917B2
公开(公告)日：2017-05-16
申请号：US13825958
申请日：2010-09-24
申请人： Timothy Stewart , Alan Tweedie , Michael Hatrick
发明人： Timothy Stewart , Alan Tweedie , Michael Hatrick
摘要： A nacelle for an engine has outer and inner cowl doors that are independently rotatable about offset hinge lines. A connection device is provided for selectively connecting the outer and inner cowl doors so as to cause them to open simultaneously. The inner cowl door is arranged to rotate by a greater angle than the outer cowl door so as to improve access to the engine for maintenance purposes.
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公开(公告)号：US08557967B2
公开(公告)日：2013-10-15
申请号：US13476878
申请日：2012-05-21
IPC分类号： C07K16/00
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/564 , G01N33/6866 , G01N2333/56 , G01N2800/042 , G01N2800/24
摘要： The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention further relates to the use of such anti-IFN-α antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-α, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
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公开(公告)号：US20070048311A1
公开(公告)日：2007-03-01
申请号：US11423588
申请日：2006-06-12
申请人： Anan Chuntharapai , Jin Kim , Leonard Presta , Timothy Stewart
发明人： Anan Chuntharapai , Jin Kim , Leonard Presta , Timothy Stewart
IPC分类号： A61K39/395
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/564 , G01N33/6866 , G01N2333/56 , G01N2800/042 , G01N2800/24
摘要： The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention further relates to the use of such anti-IFN-α antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-α, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
摘要翻译： 本发明一般涉及对各种IFN-α亚型具有广泛反应性的中和抗IFN-α单克隆抗体的产生和表征。 本发明还涉及这种抗-IFN-α抗体在诊断和治疗与IFN-α表达增加相关的疾病中的用途，特别是自身免疫性疾病如胰岛素依赖性糖尿病（IDDM）和系统性红斑狼疮 （SLE）。
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公开(公告)号：US20070015700A1
公开(公告)日：2007-01-18
申请号：US11333773
申请日：2006-01-17
申请人： David Lewin , Timothy Stewart
发明人： David Lewin , Timothy Stewart
IPC分类号： A01K67/027 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C12N9/1205 , C07K14/575
摘要： Genes are disclosed that are differentially-regulated during feeding and fasting cycles. These genes, and their encoded polypeptides are useful to combat obesity.
摘要翻译： 公开了在进食和空腹循环期间差异调节的基因。 这些基因及其编码的多肽可用于抵抗肥胖症。
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公开(公告)号：US20060294612A1
公开(公告)日：2006-12-28
申请号：US11278477
申请日：2006-04-03
申请人： David Lewin , Timothy Stewart
发明人： David Lewin , Timothy Stewart
IPC分类号： C12Q1/68 , G01N33/567 , A01K67/027 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/72 , C07K16/28
CPC分类号： C07K14/5759 , A61K38/00 , C07K14/705
摘要： A novel G-protein coupled receptor-like retinoic acid induced molecule was identified as being differentially expressed (GPCR-like RAIG1) in an animal model of fasting and feeding. Compositions and methods pertaining to treatment and diagnosis of various metabolic disorders, such as cachexia and obesity.
摘要翻译： 在禁食和喂食的动物模型中，鉴定出新型G蛋白偶联受体样视黄酸诱导分子为差异表达（GPCR样RAIG1）。 关于治疗和诊断各种代谢疾病如恶病质和肥胖症的组合物和方法。
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公开(公告)号：US20060073547A1
公开(公告)日：2006-04-06
申请号：US10226486
申请日：2002-08-22
申请人： Luc Desnoyers , Dan Eaton , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Timothy Stewart , Colin Watanabe , William Wood , Zemin Zhang
发明人： Luc Desnoyers , Dan Eaton , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Timothy Stewart , Colin Watanabe , William Wood , Zemin Zhang
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060040351A1
公开(公告)日：2006-02-23
申请号：US10973115
申请日：2004-10-22
申请人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050227328A1
公开(公告)日：2005-10-13
申请号：US11129762
申请日：2005-05-13
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号： A61K38/00 , A61K39/395 , C07K14/47 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/12 , C12N15/62 , C12N15/63 , C07H21/04 , C07K16/18 , C12N9/00 , C12N15/09
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050191725A1
公开(公告)日：2005-09-01
申请号：US11100289
申请日：2005-04-05
申请人： Audrey Goddard , Paul Godowski , Austin Gurney , Timothy Stewart , William Wood
发明人： Audrey Goddard , Paul Godowski , Austin Gurney , Timothy Stewart , William Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050170440A1
公开(公告)日：2005-08-04
申请号：US11056562
申请日：2005-02-11
申请人： Venita DeAlmeida , Timothy Stewart
发明人： Venita DeAlmeida , Timothy Stewart
IPC分类号： G01N33/53 , A61B20060101 , A61K20060101 , A61K31/175 , A61K31/64 , A61K38/00 , A61K38/17 , A61K38/18 , A61K38/22 , A61K38/28 , A61K45/00 , A61P20060101 , A61P3/04 , A61P3/10 , C07K14/435 , C07K14/47 , C07K16/18 , C07K16/46 , C12N20060101 , C12N5/10 , C12N5/12 , C12N15/09 , C12P21/08 , C12Q1/25 , G01N20060101 , G01N33/537 , G01N33/543 , G01N33/567 , G01N33/577 , G01N33/68
CPC分类号： A61K31/175 , A61K31/64 , A61K38/1709 , C07K14/4703 , G01N33/6893 , G01N2800/042 , G01N2800/044
摘要： Dickkopf-5 (Dkk-5) protein is administered in effective amounts to treat disorders involving insulin resistance, such as non-insulin-dependent diabetes mellitus (NIDDM) or obesity. Also provided is a method of diagnosing insulin resistance and related disorders using Dkk-5 as a measure, and kits for diagnosis and treatment, as well as hybridomas producing antibodies to Dkk-5 and preparations comprising Dkk-5.
摘要翻译： 以有效量施用Dickkopf-5（Dkk-5）蛋白，以治疗涉及胰岛素抵抗的疾病，例如非胰岛素依赖型糖尿病（NIDDM）或肥胖症。 还提供了使用Dkk-5作为测量来诊断胰岛素抵抗和相关疾病的方法，以及用于诊断和治疗的试剂盒，以及产生Dkk-5抗体的杂交瘤和包含Dkk-5的制剂。
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