Invention Application
US20050026907A1 Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease
失效
羰基化合物作为组蛋白脱乙酰酶的抑制剂用于治疗疾病
- Patent Title: Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease
- Patent Title (中): 羰基化合物作为组蛋白脱乙酰酶的抑制剂用于治疗疾病
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Application No.: US10865743Application Date: 2004-06-10
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Publication No.: US20050026907A1Publication Date: 2005-02-03
- Inventor: Paul Wash , Brandon Wiley , Christian Hassig , James Malecha , Stewart Noble
- Applicant: Paul Wash , Brandon Wiley , Christian Hassig , James Malecha , Stewart Noble
- Applicant Address: US CA San Diego
- Assignee: Kalypsys, Inc.
- Current Assignee: Kalypsys, Inc.
- Current Assignee Address: US CA San Diego
- Main IPC: C07C323/49
- IPC: C07C323/49 ; C07C323/67 ; C07C327/30 ; C07D277/16 ; C07D277/36 ; C07D295/112 ; C07D319/18 ; C07D417/12 ; A61K31/55 ; A61K31/19 ; A61K31/401 ; A61K31/445
Abstract:
Disclosed herein are carbonyl compounds of Formula I, II, or III, and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, autoimmune diseases and cardiovascular conditions, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
Public/Granted literature
- US07271195B2 Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease Public/Granted day:2007-09-18
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