发明申请
US20050026967A1 Inhibitors of c-jun N terminal kinases (JNK) and other protein kinases
失效
c-jun N末端激酶（JNK）和其他蛋白激酶的抑制剂
- 专利标题： Inhibitors of c-jun N terminal kinases (JNK) and other protein kinases
- 专利标题（中）： c-jun N末端激酶（JNK）和其他蛋白激酶的抑制剂
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申请号： US10779532申请日： 2004-02-13
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公开(公告)号： US20050026967A1公开(公告)日： 2005-02-03
- 发明人: Jeremy Green , Guy Bemis , Anne-Laure Grillot , Mark Ledeboer , Francesco Salituro , Edmund Harrington , Huai Gao , Christopher Baker , Jingrong Cao , Michael Hale
- 申请人： Jeremy Green , Guy Bemis , Anne-Laure Grillot , Mark Ledeboer , Francesco Salituro , Edmund Harrington , Huai Gao , Christopher Baker , Jingrong Cao , Michael Hale
- 主分类号： A61K31/341
- IPC分类号： A61K31/341 ; A61K31/4155 ; A61K31/4192 ; A61K31/42 ; A61K31/4439 ; A61K31/4545 ; A61K31/506 ; A61K31/5377 ; A61P1/04 ; A61P1/16 ; A61P1/18 ; A61P3/10 ; A61P7/02 ; A61P7/04 ; A61P7/06 ; A61P9/00 ; A61P9/10 ; A61P11/02 ; A61P11/06 ; A61P13/12 ; A61P17/00 ; A61P17/06 ; A61P19/02 ; A61P19/08 ; A61P19/10 ; A61P21/02 ; A61P21/04 ; A61P25/00 ; A61P25/14 ; A61P25/16 ; A61P25/28 ; A61P29/00 ; A61P31/00 ; A61P35/00 ; A61P35/02 ; A61P37/00 ; A61P37/02 ; A61P37/06 ; A61P37/08 ; A61P43/00 ; C07D413/04 ; C07D413/14 ; C07D261/06 ; A61K31/34 ; A61K31/505
摘要：
The present invention provides compounds of formula I: where R1 is H, CONH2, T(n)—R, or T(n)—Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.