发明申请
US20050032693A1 Novel polypeptides, their nucleic acids, and methods for their use in angiogenesis and vascularization
审中-公开
新型多肽，其核酸，及其用于血管生成和血管形成的方法
- 专利标题： Novel polypeptides, their nucleic acids, and methods for their use in angiogenesis and vascularization
- 专利标题（中）： 新型多肽，其核酸，及其用于血管生成和血管形成的方法
-
申请号： US10811080申请日： 2004-03-26
-
公开(公告)号： US20050032693A1公开(公告)日： 2005-02-10
- 发明人: Mary Gerritsen , Audrey Goddard , J. Grimaldi , Fuad Mehraban
- 申请人： Mary Gerritsen , Audrey Goddard , J. Grimaldi , Fuad Mehraban
- 申请人地址： US CA South San Francisco US CT New Haven
- 专利权人： Genentech, Inc.,Curagen Corporation
- 当前专利权人： Genentech, Inc.,Curagen Corporation
- 当前专利权人地址： US CA South San Francisco US CT New Haven
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; A61K31/7088 ; A61K38/00 ; A61K39/395 ; A61K45/00 ; A61K48/00 ; A61P7/00 ; A61P9/10 ; A61P17/00 ; A61P35/00 ; C07K14/47 ; C07K16/18 ; C07K16/46 ; C12M1/00 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N7/00 ; C12N15/09 ; C12N15/12 ; C12P21/02 ; C12P21/08 ; C12Q1/02 ; C12Q1/68 ; C12R1/91 ; C12R1/93 ; G01N33/15 ; G01N33/53 ; G01N33/566 ; G01N37/00 ; A61K38/17 ; C07H21/04
摘要：
The present invention is directed to novel polypeptides critical for angiogenesis and vascularization, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or neo- or cardio-vascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds; various cancers, and disorders of the vessels including atherosclerosis.
信息查询
IPC分类:
