-
1.发明申请Novel polypeptides, their nucleic acids, and methods for their use in angiogenesis and vascularization 审中-公开新型多肽，其核酸，及其用于血管生成和血管形成的方法公开(公告)号：US20050032693A1
公开(公告)日：2005-02-10
申请号：US10811080
申请日：2004-03-26
申请人： Mary Gerritsen , Audrey Goddard , J. Grimaldi , Fuad Mehraban
发明人： Mary Gerritsen , Audrey Goddard , J. Grimaldi , Fuad Mehraban
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P7/00 , A61P9/10 , A61P17/00 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/46 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , C12R1/93 , G01N33/15 , G01N33/53 , G01N33/566 , G01N37/00 , A61K38/17 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00 , C12N2799/027
摘要： The present invention is directed to novel polypeptides critical for angiogenesis and vascularization, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or neo- or cardio-vascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds; various cancers, and disorders of the vessels including atherosclerosis.
摘要翻译： 本发明涉及对血管生成和血管形成临界的新型多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 公开了用于刺激或抑制哺乳动物（包括人）中的血管发生和/或新生血管或心脏血管形成的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如伤口; 各种癌症和包括动脉粥样硬化的血管紊乱。
-
公开(公告)号：US20060127983A1
公开(公告)日：2006-06-15
申请号：US11296155
申请日：2005-12-06
申请人： Kevin Baker , David Botstein , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Mary Napier , Margaret Roy , Daniel Tumas , William Wood
发明人： Kevin Baker , David Botstein , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Mary Napier , Margaret Roy , Daniel Tumas , William Wood
CPC分类号： C07K14/475 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/70578 , C07K16/18 , C07K2317/24 , C07K2319/00 , C07K2319/02 , C12N2799/026 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/5085 , G01N33/57484 , G01N33/68
摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
-
公开(公告)号：US20050084935A1
公开(公告)日：2005-04-21
申请号：US10897360
申请日：2004-07-21
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , G01N33/50 , G01N33/574 , G01N33/68 , C12P21/02 , C07H21/04 , C12N9/00
CPC分类号： G01N33/5008 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K2319/00 , C07K2319/30 , C12N2799/026 , C12N2799/027 , G01N33/5011 , G01N33/502 , G01N33/57484 , G01N33/68 , G01N33/6845
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
-
公开(公告)号：US20050079577A1
公开(公告)日：2005-04-14
申请号：US10893802
申请日：2004-07-16
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07H21/04 , C12N9/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4703 , C07K14/705 , C07K2319/00 , C07K2319/30 , C12N2799/026 , C12N2799/027
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
-
公开(公告)号：US20060160186A1
公开(公告)日：2006-07-20
申请号：US11376673
申请日：2006-03-14
申请人： Dan Eaton , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Colin Watanabe , William Wood
发明人： Dan Eaton , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Colin Watanabe , William Wood
IPC分类号： C07H21/04 , C12P21/06 , C12N1/21 , C07K14/705 , C07K14/525
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
-
公开(公告)号：US20060105427A1
公开(公告)日：2006-05-18
申请号：US11296092
申请日：2005-12-06
申请人： Kevin Baker , David Botstein , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Mary Napier , Margaret Roy , Daniel Tumas , William Wood
发明人： Kevin Baker , David Botstein , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Mary Napier , Margaret Roy , Daniel Tumas , William Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
-
公开(公告)号：US20060051779A1
公开(公告)日：2006-03-09
申请号：US11103195
申请日：2005-04-11
申请人： Dan Eaton , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Colin Watanabe , William Wood
发明人： Dan Eaton , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Colin Watanabe , William Wood
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
-
公开(公告)号：US20060008901A1
公开(公告)日：2006-01-12
申请号：US10063703
申请日：2002-05-08
申请人： Dan Eaton , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Colin Watanabe , William Wood
发明人： Dan Eaton , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Colin Watanabe , William Wood
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4748 , C07K14/705 , C07K14/82 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K16/40 , C07K2319/30 , C12N5/06 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
-
9.发明申请Antibodies to polypeptides encoded by a nucleic acid underexpressed in esophageal tumor 有权由在食管肿瘤中未表达的核酸编码的多肽的抗体公开(公告)号：US20050260647A1
公开(公告)日：2005-11-24
申请号：US11102240
申请日：2005-04-08
申请人： Dan Eaton , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Colin Watanabe , William Wood
发明人： Dan Eaton , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Colin Watanabe , William Wood
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57484
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
-
公开(公告)号：US20050187382A1
公开(公告)日：2005-08-25
申请号：US10950374
申请日：2004-09-23
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Sherman Fong , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Ivar Kljavin , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , Colin Watanabe , P. Williams , William Wood , Zemin Zhang
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Sherman Fong , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Ivar Kljavin , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , Colin Watanabe , P. Williams , William Wood , Zemin Zhang
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
-
-
-
-
-
-
-
-
-
搜索结果
57 条记录 (耗时 0.057 秒)
