Invention Application
US20050037476A1 Modified Wee1, crystals of peptide: inhibitor complexes containing such modified Wee1, and methods of use thereof
审中-公开
修饰的Wee1，含有这种修饰的Wee1的肽的结晶：抑制剂复合物及其使用方法
- Patent Title: Modified Wee1, crystals of peptide: inhibitor complexes containing such modified Wee1, and methods of use thereof
- Patent Title (中): 修饰的Wee1，含有这种修饰的Wee1的肽的结晶：抑制剂复合物及其使用方法
-
Application No.: US10837652Application Date: 2004-05-04
-
Publication No.: US20050037476A1Publication Date: 2005-02-17
- Inventor: Edward Baker , Richard Booth , Alan Kraker , Daniel Ortwine , James Dickson , Ivan Ivanovic , Christopher Squire
- Applicant: Edward Baker , Richard Booth , Alan Kraker , Daniel Ortwine , James Dickson , Ivan Ivanovic , Christopher Squire
- Assignee: Pfizer Inc
- Current Assignee: Pfizer Inc
- Main IPC: C12N9/12
- IPC: C12N9/12 ; C12Q1/48 ; G01N33/68 ; G06F19/00 ; G01N33/48 ; G01N33/50 ; C12N9/99 ; C12N9/22
Abstract:
Modified Wee1 peptides, polynucleotides encoding those peptides, and methods for purifying the peptides and crystallizing them as peptide: inhibitor complexes have been discovered. The three-dimensional structure of Wee1, including the ATP substrate binding site, and uses of this information in the design and screening of compounds that may associate with Wee1, or peptides structurally related thereto, have also been discovered.
Information query
