A gas-fired water heater is provided with a combustion shutoff system which precludes further combustion within the water heater's combustion chamber in response to a combustion temperature therein reaching a predetermined level correlated to and indicative of a predetermined, undesirably high concentration of carbon monoxide present in the combustion chamber. In various illustrated embodiments thereof, the combustion shutoff system is operative to terminate further combustion air inflow to the combustion chamber, or terminate further fuel flow to the burner portion of the water heater.