Methods and compositions for monitoring progression of huntington's disease
    5.
    发明授权
    Methods and compositions for monitoring progression of huntington's disease 失效
    监测亨廷顿病进展的方法和组成

    公开(公告)号:US08506957B2

    公开(公告)日:2013-08-13

    申请号:US11792758

    申请日:2005-12-07

    IPC分类号: A61K39/395 G01N33/68

    摘要: The invention relates to a method of diagnosis of Huntington's Disease in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an altered concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being selected from: Swiss Prot accession number: Protein name; P10909: Clusterin precursor; P00738: Haptoglobin precursor; P01009: Alpha-1-antitrypsin precursor; P01024: Complement C3 precursor; P01620: 1g kappa chain V-III region; P01834: 1 g kappa chain C region P01842: 1g lambda chain C regions; P01857: 1g gamma-1 chain C region; P01859: Ig gamma-2 chain C region; P01876: 1g alpha-1 chain C region P02647: Apolipoprotein A-I precursor; P02649: Apolipoprotein E precursor; P02652: Apolipoprotein A-II precursor; P02655: Apolipoprotein C-II precursor; P02656: Apolipoprotein C-II precursor P02671: Fibrinogen alpha/alpha-E chain precursor; P02763: Alpha-1-acid glycoprotein 1 precursor; P02766: Transthyretin precursor; P02768: Serum albumin precursor; P02787: Serotransferrin precursor; P04196: Histidine-rich glycoprotein precursor; P06727: Apolipoprotein A-IV precursor; P19652: Alpha-1-acid glycoprotein 2 precursor; P68871/P02042: Hemoglobin beta chain/Hemoglobin delta chain; P60709: Beta actin.

    摘要翻译: 本发明涉及一种在人受试者的有效身体组织的诊断样本中诊断亨廷顿病的方法,其包括检测诊断样品中蛋白质的浓度变化,与对照人受试者的样品相比, 该蛋白质选自:瑞士抗原登录号:蛋白质名称; P10909:Clusterin前体; P00738:近红球蛋白前体; P01009:α-1-抗胰蛋白酶前体; P01024:补体C3前体; P01620:1gκ链V-III区; P01834:1g卡巴链C区P01842:1gλ链C区; P01857:1gγ-1链C区; P01859:Igγ-2链C区; P01876:1gα-1链C区P02647:载脂蛋白A-1前体; P02649:载脂蛋白E前体; P02652:载脂蛋白A-II前体; P02655:载脂蛋白C-II前体; P02656:载脂蛋白C-II前体P02671:纤维蛋白原α/α-E链前体; P02763:α-1-酸性糖蛋白1前体; P02766:曲氨酸蛋白前体; P02768:血清白蛋白前体; P02787:血清转铁蛋白前体; P04196:富含组氨酸糖蛋白前体; P06727:载脂蛋白A-IV前体; P19652:α-1酸性糖蛋白2前体; P68871 / P02042:血红蛋白β链/血红蛋白三角链; P60709:β肌动蛋白

    FISH HOOK CLEANING TOOL
    7.
    发明申请
    FISH HOOK CLEANING TOOL 审中-公开
    鱼钩清洁工具

    公开(公告)号:US20120060298A1

    公开(公告)日:2012-03-15

    申请号:US12878033

    申请日:2010-09-09

    申请人: James Campbell

    发明人: James Campbell

    IPC分类号: A01K97/00

    CPC分类号: A01K97/00 B24D15/02 B24D15/06

    摘要: A fish hook cleaning tool comprising a tapered body including a blunt end and a pointed end, a hole within the blunt end, a tip along the pointed end, and a textured material within the hole and on the pointed end wherein the textured material enables a user to clean and file a fish hook to remove a particulate from the fish hook and to sharpen the fish hook between uses. The tip of the pointed end is sharp enough to fit within an eyelet of the fish hook to clean the particulate within the eyelet to more easily thread a fishing line.

    摘要翻译: 一种鱼钩清洁工具,其包括锥形体,其包括钝端和尖端,钝端内的孔,沿着尖端的尖端,以及在孔内和尖端上的纹理材料,其中纹理材料使得 用户清洁并提起鱼钩以从鱼钩中除去颗粒物,并在使用之间锐化鱼钩。 尖端的尖端足够锐利,以适合鱼钩的孔眼以清洁孔眼内的颗粒,以更容易地钓鱼线。

    ISOLATION AND PRESENTATION OF UNTRUSTED DATA
    8.
    发明申请
    ISOLATION AND PRESENTATION OF UNTRUSTED DATA 有权
    隔离和介绍非数据资料

    公开(公告)号:US20110099609A1

    公开(公告)日:2011-04-28

    申请号:US12607074

    申请日:2009-10-28

    IPC分类号: G06F21/00 G06F3/00 G06F15/16

    摘要: Architecture that provides a secure environment in which data (e.g., code, instructions, files, images, etc.) can be opened and run by a client application. Once opened the data can be viewed (in a “protected view”) by the user without incurring risk to other client processing and systems. Accordingly, the architecture mitigates malicious attacks by enabling users to preview untrusted and potentially harmful data (e.g., files) in a low risk manner. Files opened in the protected view are isolated from accessing key resources on the client computer and provides the user a safer way to read files that can contain dangerous content. The protected view also provides a seamless user experience. The user is unaware that the client is operating on data in a different mode and allows for the reduction of security prompts.

    摘要翻译: 提供安全环境的架构,其中可以由客户端应用程序打开和运行数据(例如,代码,指令,文件,图像等)。 一旦打开,用户可以查看(在“受保护的视图”)中的数据,而不会对其他客户端处理和系统造成风险。 因此,该架构通过使用户能够以低风险的方式来预览不可信和潜在的有害数据(例如,文件)来减轻恶意攻击。 在受保护视图中打开的文件与访问客户端计算机上的密钥资源是隔离的,并为用户提供了一种更安全的方式来读取可能包含危险内容的文件。 受保护的视图还提供无缝的用户体验。 用户不知道客户端以不同的模式操作数据,并允许减少安全提示。

    Facilitating Arrangement in a Communication System
    9.
    发明申请
    Facilitating Arrangement in a Communication System 有权
    促进通信系统的安排

    公开(公告)号:US20100211604A1

    公开(公告)日:2010-08-19

    申请号:US12523608

    申请日:2008-01-18

    IPC分类号: G06F15/16 G06F17/30

    摘要: A method for determining the availability of at least one target user for a specific type of communication is described. The method comprises: retrieving contact information of at least one target user from a memory of a requesting user terminal; sending a request for communication status information of the at least one target user to a status network element, the status network element being arranged to provide the communication status information regarding the availability of the target user for the specific type of communication, wherein the request comprises at least a portion of the contact information of the at least one target user and identifies the specific type of communication; receiving, as a response to the request, a response message from the status network element, wherein the response message comprises the communication status information of the at least one target user; and modifying at least a portion of stored contact information when the received status information indicates that the target user is available for communication via the specific communication type, such that the modified contact information indicates on the requesting user terminal the current availability of the at least one user for communication via the specific communication type.

    摘要翻译: 描述了用于确定用于特定类型的通信的至少一个目标用户的可用性的方法。 该方法包括:从请求用户终端的存储器检索至少一个目标用户的联系人信息; 向所述状态网络单元发送对所述至少一个目标用户的通信状态信息的请求,所述状态网络单元被布置为提供关于所述特定类型的通信的目标用户的可用性的通信状态信息,其中所述请求包括 所述至少一个目标用户的所述联系信息的至少一部分,并且识别所述特定通信类型; 从所述状态网络单元接收响应于所述请求的响应消息,其中所述响应消息包括所述至少一个目标用户的通信状态信息; 以及当所接收的状态信息指示所述目标用户可用于经由所述特定通信类型进行通信时,修改所存储的联系人信息的至少一部分,使得所述修改的联系人信息在所述请求用户终端上指示所述至少一个 用户通过特定通信类型进行通信。